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Effect of enteral nutrition suspension on immune function in severe acute pancreatitis patients with intestinal bacterial translocation

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Author:
No author available
Journal Title:
World Chinese Journal of Digestology
Issue:
20
DOI:
10.11569/wcjd.v26.i20.1247
Key Word:
急性重症胰腺炎;肠内营养混悬液;免疫功能;肠内营养;Acute severe pancreatitis;Enteral nutrition suspension;Immune function;Enteral nutrition

Abstract: AIM To observe the effect of enteral nutrition suspension (TPF-DM) on the immune function of acute severe pancreatitis patients with intestinal flora translocation.METHODS One hundred and ten acute severe pancreatitis patients with intestinal flora translocation treated at Jiuli Songyuan District People's Liberation Army No.117 Hospital were randomly divided into either a control group or a TPF-DM group (n = 55 each). The control group was treated with conventional therapy, while the TPF-DM group were treated with TPF-DM. The levels of inflammatory indexes [white blood cell (WBC) and C-reactive protein (CRP) ], biochemical indicators [albumin (ALB), amylase (AMY), and endothelin (ET) ], and immune markers (IgG, IgM, and IgA) were recorded at admission, 7 and 14 d after treatment. Time to abdominal pain disappearance, hospitalization time, hospitalization costs, and mortality rate were also compared in the two groups.RESULTS At admission, there was no significant difference in the levels of WBC, CRP, ALB, AMY, ET, Ig G, Ig M, or IgA between the two groups (P> 0.05). At 7 d and 14 d after treatment, the WBC and CRP levels of the two groups showed a decreasing trend (P< 0.05). The WBC and CRP levels at 7 and 14 d after treatment were significantly lower in the TPF-DM group than in the control group (P< 0.05). At 7 d and 14 d after treatment, ALB showed a decreasing trend in both groups, and the AMY and ET levels showed a trend of increasing (P< 0.05). The ALB levels in the TPF-DM group were significantly higher than those in the control group at 7 d and 14 d after treatment, and the levels of AMY and ET were significantly lower than those in the control group (P< 0.05). There was no significant difference in the time to disappearance of abdominal pain, hospital stay, hospitalization costs, or mortality between the twogroups (P> 0.05). At 7 d and 14 d after treatment, the levels of Ig G, Ig M, and Ig A in both groups showed a trend of increase (P< 0.05), and the levels of IgG, IgM, and Ig A at 7 and 14 d after treatment in the TPF-DM group were significantly higher than those in the control group (P< 0.05).CONCLUSION TPF-DM can effectively treat severe acute pancreatitis patients with intestinal bacterial translocation by improving their inflammatory status and immune function.

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