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Effect of adding on telbivudine or switching to telbivudine alone on therapeutic efficacy and renal function in chronic hepatitis B patients on adefovir dipivoxil monotherapy

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Author:
No author available
Journal Title:
World Chinese Journal of Digestology
Issue:
14
DOI:
10.11569/wcjd.v26.i14.862
Key Word:
慢性乙型肝炎;肾小球率过滤;替比夫定;阿德福韦酯

Abstract: 目的 探讨阿德福韦酯(adefovir dipivoxil,ADV)经治的慢性乙型肝炎(chronic hepatitis B,CHB)患者加用替比夫定(telbivudine,L-DT)后乙型肝炎e抗原(hepatitis B e antigen,HBeAg)血清转换率,并对肾脏功能进行评价.方法 回顾性分析2013-1/2016-12应用ADV(10 mg/d)单药治疗的HBeAg阴性CHB患者42例,其中加用L-DT治疗的20例患者定义为联合组,22例换用恩替卡韦(entecavir,ETV)治疗者定义为单药组,分别在24 wk、48 wk时分析两组数据的HBeAg血清学转换率,并采用国际公认的肾脏病膳食改良试验(Modification of Diet in Renal Disease,MDRD)公式来计算两组的肾小球滤过率估计值[estimated glomerular filtration rate,eGFR=186×血清肌酐水平-1.154×年龄-0 203×1.21(黑人)]×[0.742(女性)],对两组肾脏功能进行评估.结果 分别统计两组24 wk和48 wk的eGFR,联合组的eGFR平均水平较单药组有所改善,独立样本t检验后,发现24 wk和48 wk对应的P值分别为0.773和0.108,差异无统计学意义,同时将两组48 wk时的eGFR分别与基线对比,联合组t值为-6.184,P<0.05,差异有统计学意义,单药组t值为-0.893,P>0.05,差异无统计学意义;对24 wk和48 wk不同组别患者HBeAg血清转换率进行比较,P值分别为0.043和0.034,联合组的HBeAg血清转换率优于单药组.结论 对于ADV经治的HBeAg阴性CHB患者,联合应用L-DT,可获得较高的HBeAg血清学转换,长期治疗可改善肾脏功能.

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