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ROLE OF AUTOPHAGY IN HEPATIC ISCHEMIA-REPERFUSION INJURY

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 13

DOI:: 10.11569/wcjd.v26.i13.755

Key Word:: 肝脏缺血再灌注损伤;自噬;线粒体;Liver ischemia-reperfusion injury;Autophagy;Mitochondria

Abstract： Hepatic ischemia-reperfusion injury is a common complication of liver surgery and an important cause of liver dysfunction after operation. The pathogenesis of liver ischemia-reperfusion injury is very complex, involving many factors. Autophagy is a lysosomal degradation pathway on which eukaryotic cells rely to maintain the cell homeostasis. Autophagy plays an important role in the process of liver ischemia-reperfusion injury. However, the specific role and mechanism of autophagy in liver ischemia-reperfusion injury are still controversial. In this paper, we reivew the role and mechanism of autophagy in hepatic ischemia-reperfusion injury.

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