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Hepatic artery blood flow index for predicting liver fibrosis induced by Schistosoma japonicum
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- Author:
- No author available
- Journal Title:
- World Chinese Journal of Digestology
- Issue:
- 7
- DOI:
- 10.11569/wcjd.v26.i7.434
- Key Word:
- 肝纤维化;首次通过法;肝动脉血流指数;核素
Abstract： 目的 日本血吸虫病肝纤维化,这种疾病的临床治疗在很大程度上取决于目前有限的诊断工具.本次研究应用核素首次通过法测定肝动脉血流指数(hepatic artery blood flow index,HBI)进而预测肝纤维化的程度.方法 选取67例日本血吸虫病患者参与标志物诊断价值评估研究.使用METAVIR评分系统评估纤维化程度.静脉注射二磷酸锝99后,即刻采用首次通过法测定HBI.应用SPSS软件,测定受试者操作特征曲线下面积(area under the receiver's operating characteristic curve,AUROC)作为衡量HBI预测肝纤维化的价值.结果 F1级患者与F2级和F3-F4级之间HBI(P＜0.01)与肝纤维化程度呈正相关.AUROC曲线显示,HBI预测显著肝纤维化的诊断价值是0.916(P=0.000),截止点为32.77时,敏感性为87.5％,特异性为62.5％,阳性预测值(positive predictive value,PPV)为70.0％,阴性预测值(negative predictive value,NPV)83.3％,和95％CI为0.844-0.987.此外,AUROC曲线显示,血流指数预测严重肝硬化的诊断价值为0.832(P=0.000).截止点为40.70时,敏感性为96.3％,特异性为58.8％,PPV为70.0％,NPV为96.5％,和95％CI为0.729-0.935.结论 HBI是一种新型评估肝纤维化的诊断工具.
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