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High-dose amoxicillin/esomeprazole dual therapy as a first-line therapy for Helicobacter pylori eradication

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 6

DOI:: 10.11569/wcjd.v26.i6.353

Key Word:: 幽门螺杆菌;治疗;阿莫西林;临床研究;二联方案

Abstract：目的评估大剂量阿莫西林/埃索美拉唑二联方案在幽门螺杆菌(Helicobacter pylori,H.pylori)感染初次治疗患者中的疗效及安全性.方法 142例H.pylori感染的初次治疗患者随机进入大剂量阿莫西林/埃索美拉唑二联方案(EA)组(埃索美拉唑20 mg qid+阿莫西林0.75 g qid,疗程14 d)和铋剂四联方案(EBAC)组(埃索美拉唑20 mg bid十枸橼酸铋钾220 mg bid+阿莫西林1.0 gbid+克拉霉素0.5 gbid,疗程14 d),治疗结束后6 wk复查尿素呼气试验,判断H.pylori根除疗效.结果共131例患者完成研究,EA组按意向治疗(intention-to-treat,ITT)与按方案(per-protocol,PP)分析H.pylori根除率分别为82.9％和89.2％,EBAC组分别为86.1％和93.9％,两组根除率的ITT、PP分析差异均无统计学意义(P＞0.05).按PP分析,EBAC组不良反应发生率明显高于EA组(15.2％ vs 3.1％,P＜0.05).结论大剂量阿莫西林/埃索美拉唑二联方案可作为安全、有效的H.pylori感染初次治疗方案.

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