Abstract: AIM To evaluate the effect of endoscopic intervention combined with somatostatin on clinical symptoms and biochemical indexes in patients with severe acute pancreatitis (SAP).METHODS One hundred and forty-eight patients with SAP treated from January 2015 to June 2016 at the Jiaxing First Hospital were divided into either an observation group or a control group.Both groups were given conventional therapy.The control group was given somatostatin infusion therapy,and the observation group was given endoscopic intervention combined with somatostatin artery perfusion therapy.Clinical symptoms,serum inflammatory factors,gastrointestinal hormones,and complications were compared between the two groups.RESULTS Times to remission of abdominal pain,high fever,and signs of peritoneal irritation were significantly shorter in the observation group than in the control group (t =10.720,8.226,11.840,and 9.143,respectively;P < 0.05 or 0.01).Serum levels of interleukin-8,hypersensitive C-reactive protein,and tumor necrosis factor α were significantly lower in the observation group than in the control group (t =17.509,20.189,and 14.847,respectively;P < 0.01).Serum levels of vasoactive intestinal peptide and gastrin were significantly lower and that of motilin was significantly higher in the observation group than in the control group (t =14.586,11.374,and 7.126,respectively;P < 0.05 or 0.01).The incidence of pancreatic or surrounding tissue necrosis,pancreatic fistula,pancreatic abscess,and pancreatic pseudocyst was significantly lower in the observation group than in the control group (x2 =7.306,7.955,8.976,and 5.049,respectively;P < 0.05 or 0.01).CONCLUSION Endoscopic intervention combined with somatostatin can help relieve the inflammatory response,modulate gastrointestinal function,improve the clinical symptoms,and reduce complications in patients with SAP.