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Diagnostic value of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in Crohn's disease

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Journal Title:
World Chinese Journal of Digestology
Key Word:
克罗恩病;血小板/淋巴细胞比值;中性粒细胞/淋巴细胞比值;诊断价值;Crohn's disease;Platelet-to-lymphocyte ratio;Neutrophil-to-lymphocyte ratio;Diagnostic value

Abstract´╝Ü AIM To investigate the diagnostic efficacy of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in patients with Crohn's disease (CD).METHODS EDTA anticoagulant venous blood was collected from CD patients (n =60) and healthy controls (n =60),and routine blood test was performed to obtain the neutrophilic granulocyte count,lymphocyte count,and platelet count.Then,the PLR and NLR were calculated.The sensitivity (Sen),specificity (Spe),and cut-off values were calculated by receiver operator characteristic (ROC) curve analysis.RESULTS CD patients had significantly higher PLR (181 ± 45.12 vs 86 ± 32.78) and NLR (3.07 ± 1.02 vs 2.52 ± 1.14) than healthy controls (P < 0.05).The cut-off values for PLR and NLR were 133.12 (Sen:76.21%;Spe:84.53%) and 2.85 (Sen:69.16%;Spe:76.24%),respectively,and the areas under the ROC curves for PLR and NLR were 0.764 and 0.828,respectively.CONCLUSION PLR and NLR might be effective and low-cost biomarkers for distinguishing CD patients from healthy controls.

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