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Effect of probiotics on diarrhea secondary to chemotherapy for leukemia

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Author:
No author available
Journal Title:
World Chinese Journal of Digestology
Issue:
36
DOI:
10.11569/wcjd.v25.i36.3248
Key Word:
双歧杆菌;急性淋巴细胞白血病;化疗相关性腹泻;肠黏膜屏障功能;Bifidobacterium;Acute lymphoblastic leukemia;Chemotherapy-associated diarrhea;Intestinal mucosal barrier function

Abstract: AIM To evaluate the effect of probiotics on intestinal mucosal barrier function and inflammatory cytokine levels in patients with diarrhea secondary to chemotherapy for acute lymphoblastic leukemia.METHODS Ninety patients with chemotherapy-associated diarrhea treated at Taizhou Municipal Hospital from January 2015 to December 2016 were randomly divided into a control group (n =45) and an observation group (n =45).Both groups were given montmorillonite powder-based conventional symptomatic treatment,and the observation group was additionally given Bifidobacterium triple viable capsules.Clinical efficacy,intestinal mucosal barrier function,inflammatory cytokine levels,and intestinal flora were compared between the two groups.RESULTS In the observation group,25 (55.56%) cases showed marked improvement and 17 (37.78%) cases showed improvement,with a total effective rate of 93.33%,which was significantly higher than that in the control group (75.56%;P < 0.05).Before treatment,intestinal mucosal barrier function indexes were similar between the two groups (P > 0.05);after treatment,diamine oxidase,D-lactic acid,and endothelin were significantly decreased in both groups,and the decrease was significantly more remarkable in the observation group (P < 0.05).Before treatment,inflammatory cytokines in the two groups were similar (P > 0.05);after treatment,tumor necrosis factor-α,procalcitonin,and interleukin-6 were significantly decreased in both groups,and the decrease was significantly more remarkable in the observation group (P < 0.05).The number of intestinal microbes after treatment was significantly lower than that before treatment in the control group.In the observation group,Bifidobacterium and Lactobacillus were significantly increased after treatment,and the number of intestinal microbes was significantly higher than that of the control group (P < 0.05).Enterobacteriaceae,Enterococcus,and Escherichia coli showed no significant changes between before and after treatment in the observation group (P >0.05).CONCLUSION Auxiliary application of probiotics can significantly improve the therapeutic efficacy for chemotherapyinduced diarrhea in acute lymphoblastic leukemia patients,reduce the levels of inflammatory cytokines,improve intestinal mucosal barrier function,regulate the balance of intestinal flora disturbance,and reconstruct intestinal ecological balance.

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