Abstract： AIM To investigate the effect of early dietary fiber-containing enteral nutrition on the immune function and prognosis of patients with cerebral hemorrhage. METHODS One hundred and twenty patients who underwent surgery for cerebral hemorrhage at our hospital from February 2012 to February 2017 were randomly and equally divided into an observation group, which was given early dietary fiber-containing enteral nutrition, and a control group, which was given conventional enteral nutrition support. Immunoglobulins, lymphocyte count,percentage of CD4+ T cells, percentage of CD8+ T cells,CD4+/CD8+ ratio, postoperative complications, and Glasgow Outcome Scale (GOS) score at 6 months were compared between the two groups. RESULTS On the day after surgery, there was no significant difference in IgG, IgA, IgM,lymphocyte count,percentage of CD4+ T cells, percentage of CD8+ T cells, or CD4+/CD8+ ratio between the two groups (P ＞ 0.05). Two weeks after operation, IgG, IgA, IgM, lymphocyte count, percentage of CD4+ T cells, and CD4+/CD8+ were significantly higher in the observation group than in the control group (17.19 ± 3.31 vs 11.82 ± 1.91, 2.83 ± 0.76 vs 1.89 ± 0.63, 4.08 ± 0.56 vs 2.52 ± 0.58, 2.83 ± 0.53 vs 1.29 ± 0.29, 47.56 ± 10.36 vs 32.09 ± 8.21, 1.65 ± 0.41 vs 1.09 ± 0.06, P ＜ 0.05), while the percentage of CD8+ T cells in the observation group was significantly lower than that in the control group (26.03 ± 5.98 vs 29.31 ± 5.21, P ＜ 0.05). During hospitalization, the incidence of adverse reactions was significantly higher in the control group than in the observation group (66.67％ vs 43.33％, P ＜ 0.05). Six months after operation, the GOS score was significantly higher in the observation group than in the control group (4.09 ± 0.31 vs 3.11 ± 0.23, P ＜ 0.05). CONCLUSION Early dietary fiber-containing enteral nutrition in patients with cerebral hemorrhage can significantly improve the immune status of patients, reduce the incidence of complications during hospitalization, and improve the prognosis of patients.