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Relationship between NSD2 and tumors

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Journal Title:
World Chinese Journal of Digestology
Key Word:
NSD2;组蛋白甲基转移酶;靶向治疗;多发性骨髓瘤;Nuclear receptor binding SET domain-protein 2;Histone methyltransferase;Targeted therapy;Multiple myeloma

Abstract´╝Ü Nuclear receptor binding SET domain-protein 2 (NSD2),also known as MMSET or WHSC1,is a member of the NSD family.Methylation of histone as an important regulatory mechanism in epigenetics plays an important role in transcriptional regulation and chromatin remodeling.The overexpression of NSD2,caused by t(4;14) (p16;q23) translocation,is closely related to the prognosis of patients with multiple myeloma.In addition,high expression of NSD2 can be detected in many other malignant tumors.NSD2 catalyzes the methylation of the lysine sites of histone,and promotes the initiation and progression of tumors by participating in the interaction among multiple proteins or the regulation of target genes.NSD2 and related signal molecules are expected to be the targets for treatment of various related tumors.Elucidating the mechanism of NSD2 may promote the development of targeted drugs and provide new solutions for the treatment of various NSD2-related tumors.

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