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Aldehyde dehydrogenase 2 gene polymorphisms and liver diseases

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 33

DOI:: 10.11569/wcjd.v25.i33.2981

Key Word:: 乙醛脱氢酶2;基因多态性;肝脏疾病;Aldehyde dehydrogenase 2;Gene polymorphism;Liver diseases

Abstract： Liver diseases are one of major causes of disease burden in China.The composition of chronic liver diseases has changed significantly in China over the past years.The incidence of alcoholic liver disease has increased gradually.Acetaldehyde dehydrogenase 2 (ALDH2) is the principle enzyme responsible for hepatic metabolism of ethanol.Approximately 8％ of individuals have the inactive ALDH2 genotype around the world,especially in the East Asian population.Presence of the mutant or inactive ALDH2*2 gene may lead to accumulation of acetaldehyde as the ethanol metabolite.Acetaldehyde is a toxic material which can cause multiple organs to be injured in the individuals with acetaldehyde accumulation.The relationship between the mutant ALDH2*2 gene and a variety of liver disorders including alcoholic liver disease needs to be explored.In the present article,we review the recent advances in understanding the relationship between ALDH2 gene polymorphisms and liver diseases,in order to provide a better understanding of the difference in the characteristics of liver disease between the Eastern and Western populations,which can help develop new strategies to prevent and treat liver diseases.

Reference

[1]Pakstis A,Luo HR,Wu GS.Origin and dispersal of atypical aldehyde dehydrogenase ALDH2487Lys.[J].2009,435(1).
[2]Mashiko, Setshedi,Jack R, Wands,Suzanne M de la, Monte.Acetaldehyde adducts in alcoholic liver disease.[J].1900,3(3).
[3]Caecilia HC Sukowati,Korri E El-Khobar,Susan I Ie,etc.Significance of hepatitis virus infection in the oncogenic initiation of hepatocellular carcinoma[J].2016,(4).
[4]Samir Zakhari.Bermuda Triangle for the liver: Alcohol, obesity, and viral hepatitis.[J].2013,28(Suppl.1).
[5]Yan, Zhao,Chuancai, Wang.Glu504Lys Single Nucleotide Polymorphism of Aldehyde Dehydrogenase 2 Gene and the Risk of Human Diseases.[J].2015,2015.
[6]Zheng, Shen,Joanne M, Ajmo,Christopher Q, Rogers,etc.Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines.[J].2009,296.
[7]Hiroshi Abe,Yuta Aida,Nobuyoshi Seki,etc.Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis[J].2015,30(9).
[8]Kawamoto T,Oyama T,Fujino A,etc.HBV- and HCV- infected workers in the Japanese workplace.[J].2007,49(1).
[9]Pei-Suen, Tsou,Nathaniel A, Page,Sean G, Lee,etc.Differential metabolism of organic nitrates by aldehyde dehydrogenase 1a1 and 2: substrate selectivity, enzyme inactivation, and active cysteine sites.[J].2011,13(4).
[10]Chen,C.-H.,Ferreira,J.C.B.,Gross,E.R.,etc.Targeting aldehyde dehydrogenase 2: New therapeutic opportunities[J].2014,94(1).
[11].The global burden of liver disease: The major impact of China[J].2014,60(6).
[12]Sanjuan L,Alcazar LM,Quiles R,etc.Hepatic expression of adiponectin receptors increases with non-alcoholic fatty liver disease progression in morbid obesity in correlation with glutathione peroxidase 1.[J].2011,21(4).
[13]Jianhua, Ding,Suping, Li,Jianzhong, Wu,etc.Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk of primary hepatocellular carcinoma in a Chinese population.[J].1900,9.
[14]Nagy, L. E.,Zakhari, S,Wang, H. J,etc.Inflammation in alcoholic liver disease.[J].2012,32.
[15]Murali Ganesan,Sathish Kumar Natarajan,Jinjin Zhang,etc.Role of apoptotic hepatocytes in HCV dissemination: regulation by acetaldehyde[J].2016,310(6 Pt.1).
[16]Guo, Rui,Xu, Xihui,Babcock, Sara A.,etc.Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy[J].2015,62(3).
[17]Brian, Jackson,Chad, Brocker,David C, Thompson,etc.Update on the aldehyde dehydrogenase gene (ALDH) superfamily.[J].2011,5.
[18]Rui, Guo,Jun, Ren.Alcohol dehydrogenase accentuates ethanol-induced myocardial dysfunction and mitochondrial damage in mice: role of mitochondrial death pathway.[J].2010,5(1).
[19]Dawei Li,Joel Gelernter,Hongyu Zhao.Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.[J].2012,131(5).
[20]Yingdi, Liu,Joanne, Brymora,Hongyi, Zhang,etc.Leptin and acetaldehyde synergistically promotes αSMA expression in hepatic stellate cells by an interleukin 6-dependent mechanism.[J].2011,35(5).
[21]Vishnudutt Purohit,David A. Brenner.Mechanisms of alcohol-induced hepatic fibrosis: A summary of the Ron Thurman Symposium[J].2006,43(4).
[22]Wenzel, Philip,Hink, Ulrich,Oelze, Matthias,etc.Role of Reduced Lipoic Acid in the Redox Regulation of Mitochondrial Aldehyde Dehydrogenase (ALDH-2) Activity.[J].2007,282(1).
[23]Chen CH,Sun L,Mochly Rosen D.Mitochondrial aldehyde dehydrogenase and cardiac diseases.[J].2010,88(1).
[24]Park, Byoungjin,Lee, Hye-Ree,Lee, Yong-Jae.Alcoholic liver disease: focus on prodromal gut health[J].2016,17(8).
[25]Y, Mizoi,K, Yamamoto,Y, Ueno,etc.Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism.[J].1994,29.
[26]Murali Ganesan,Jinjin Zhang,Tatiana Bronich,etc.Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells[J].2015,309(4 Pt.1).