Abstract: As an endogenous inhibitor of the Wnt signaling pathway,Dickkopf-1 (DKK1) plays an important role in the occurrence and development of tumors.However,the role of DKK1 in different tumor types is different,as it is lowly expressed in some tumor types,but over-expressed in others.In recent years,there have been many studies on the role of DKK1 in gastrointestinal tumors.In this paper,we review the latest progress in the understanding of the role of DKK1 in gastrointestinal tumors.