Abstract： Functional dyspepsia (FD) is a common digestive disease that is associated with many psychological factors.Modern medicine considers that the pathogenesis of FD is closely related to the effects of the brain-gut axis on the digestive system,but there is still a lack of objective biomarkers for the diagnosis and evaluation of this disease.In recent years,the application of metabonomics to study the pathological changes of metabolites has become a hot spot.Traditional Chinese medicine considered that hepatic stagnation and spleen deficiency is largely responsible for the pathogenesis of FD.The metabonomics study of FD coincides with the concept of holisms and the principle of treatment based on syndrome differentiation in TCM.Nowadays,great progress has been made in the intervention of metabolites changes by acupuncture,Chinese herbal medicine and other methods.This paper will review the recent progress in the metabonomics research of functional dysplasia of hepatic stagnation and spleen deficiency type.