Abstract： AIM To investigate the expression of Notch 1 receptor in liver tissues with the degree of hepatic fibrosis in patients with chronic hepatitis B (CHB).METHODS A total of 50 patients with CHB confirmed by liver biopsy were enrolled in the study.The degree of hepatic fibrosis was evaluated by Masson's trichromatic staining.The expression of Notch1 receptor in liver tissue was detected by immunohistochemistry.The association between Notch1 receptor expression and the degree of hepatic fibrosis was analyzed.RESULTS Masson's trichromatic staining showed that the percentage of liver collagen fiber area was 3.46％ ± 0.41％ in group S0,6.95％ ± 0.96％ in group S1,9.88％ ± 1.12％ in group S2,15.86 ± 1.82 in group S3,and 23.13％ ± 2.17％ in group S4;there was a significant difference among different groups (P ＜ 0.05).The positive score of Notch1 receptor expression was 0 in group S0,1.53 ± 0.28 in group S1,2.01 ± 0.79 in group S2,2.86 ± 1.13 in group S3,3.81 ± 1.76 in group S4;there was a significant difference among different groups (P ＜ 0.05).There was a positive correlation between liver collagen fiber area and the intensity of Notch1 receptor (r =0.486,P =0.001).CONCLUSION Notch1 receptor expression increases in liver tissue of chronic hepatitis B patients,and abnormal expression of Notch1 receptor might be involved in the progression of hepatic fibrosis.