Abstract: Exosomes are extracellular vesicles with a diameter of 30-100 nm secreted by various cells,which can exert diverse effects by transferring their contents to the recipient cells.Gastric cancer is one of the common malignant tumors of the digestive system,with high morbidity and mortality.There is growing evidence that exosomes play a key role in the biological behavior of gastric cancer.This review describes the role of tumor-derived exosomes in the tumorigenesis,proliferation,recurrence,metastasis,immune escape,drug resistance,early diagnosis,and biotherapy in gastric cancer,and discusses their potential use in marker detection and treatment in this malignancy.