Abstract: Endoscopic ultrasound (EUS)-guided interventional therapy is an important research direction of EUS,and it mainly includes EUS-guided celiac plexus neurolysis (EUS-CPN),EUS-guided pseudocyst drainage,EUS-guided biliary drainage (EUS-BD),and EUS-guided fine needle injection (EUS-FNI).The therapeutic effect of EUS-CPN was superior to that of traditional analgesic therapy.No matter whether the first CPN therapy is effective,the effect of a second CPN is limited.Choosing unilateral or bilateral injection is related to operators' habits and proficiency,and there is no obvious difference in therapeutic effect.EUS-guided pseudocyst drainage is the best choice for patients who have the indications for drainage.The efficacy and safety of EUS-BD have been confirmed.EUS-guided ethanol injection is currently the best therapeutic method for patients with pancreatic neuroendocrine tumors who are not suitable for or unwilling to undergo surgery.The therapeutic value of EUS-RFA and EUS-FNI for pancreatic cancer remains to be further confirmed.