Abstract： AIM To explore the influence of matrine combined with Weifuchun tablets on gastric acid secretion in patients with chronic atrophic gastritis (CAG).METHODS One hundred and sixty patients with CAG were included and equally divided into either a control group or a study group.The control group was treated with Weifuchun alone,and the study group was treated with Weifuchun tablets combined with matrine.The gastric juice,pathological score,gastroscopic findings before and after treatment,and clinical efficacy between the two groups were compared.RESULTS After treatment,pH value,free acid,bile acid,and pepsin were significantly improved in both groups (P ＜ 0.05),and the improvement was significantly better in the study group than in the control group (P ＜ 0.05).The atrophy,intestinal metaplasia,and dysplasia scores were significantly reduced in both groups (P ＜ 0.05),and these scores were significantly lower in the study group than in the control group (P ＜ 0.05).The proportion of patients with ulcer,congestion,edema,erosion,erosion,or bleeding as revealed by gastroscopy was significantly lower in the study group than in the control group (P ＜ 0.05).The total effective rate was significantly higher in the study group than in the control group (93.8％ vs 86.2％,P ＜ 0.05).CONCLUSION Matrine combined with Weifuchun tablets can effectively reverse the precancerous lesions,improve curative effect,and restore gastric acid secretion in patients with CAG.