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New recognition of gut microbiota and related diseases

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 23

DOI:: 10.11569/wcjd.v25.i23.2095

Key Word:: 肠道菌群;肠道健康;粪菌移植;益生菌;Gut microbiota;Gut health;Fecal microbiota transplantation;Probiotics

Abstract： The gut microbiota (GM),playing a critical role in many physiological processes,is regarded as an important "organ" in the human body.The dysbiosis of GM is related to metabolic syndrome,autoimmune disorders,and certain types of tumors.Infection with opportunistic pathogens will give rise to some severe illnesses.Currently,fecal microbiota transplantation,probiotic supplement and antibiotics are major therapeutic measures for intestinal flora disturbance.Clinical treatment of Clostridium difficile infection by fecal microbiota transplantation has shown satisfactory curative effects.As research continues,GM may become a new research direction for the prevention and control of multiple diseases in the future.

Reference

[1]Liam, Drew.Microbiota: Reseeding the gut.[J].2016,(7634).
[2].Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor−κB, and Up-regulating Expression of MicroRNA-21[J].2017,152(4).
[3]Colman, Ruben J.,Rubin, David T..Fecal microbiota transplantation as therapy for inflammatory bowel disease: A systematic review and meta-analysis[J].2014,8(12).
[4]Yao, Wei,Jianfeng, Gong,Weiming, Zhu,etc.Pectin enhances the effect of fecal microbiota transplantation in ulcerative colitis by delaying the loss of diversity of gut flora.[J].2016,(1).
[5]Jiang,Z.,Mayer,E.A.,Labus,J.,etc.Consumption of fermented milk product with probiotic modulates brain activity[J].2013,144(7).
[6]Ting Yu,Jia-Cheng Tan,Wen-Jie Xiong,etc.Effects of Prebiotics and Synbiotics on Functional Constipation[J].2017,353(3).
[7]Paul W, O'Toole,Julian R, Marchesi,Colin, Hill.Next-generation probiotics: the spectrum from probiotics to live biotherapeutics.[J].2017,2(Spec ).
[8]Marchesi, J.R.,Tjalsma, H.,Boleij, A.,etc.A bacterial driver-passenger model for colorectal cancer: Beyond the usual suspects[J].2012,10(8).
[9]Levy, Maayan,Blacher, Eran,Elinav, Eran.Microbiome, metabolites and host immunity[J].2017,35.
[10]mohy.Dnan,JohnF.Cryan.Gut-brain axis in 2016: Brain-gut-microbiota axis - mood, metabolism and behaviour[J].2017,14(2).
[11]J D, Bennet,M, Brinkman.Treatment of ulcerative colitis by implantation of normal colonic flora.[J].1989,1(8630).
[12]Ahn,J.,Sinha,R.,Pei,Z.,etc.Human gut microbiome and risk for colorectal cancer[J].2013,105(24).
[13]Huso, D.L.,Goodwin, A.C.,Sears, C.L.,etc.Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis[J].2011,108(37).
[14]Walid, Mottawea,Cheng-Kang, Chiang,Marcus, Mühlbauer,etc.Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease.[J].2016,(Spec ).
[15]Krautkramer, Kimberly A.,Kreznar, Julia H.,Romano, Kymberleigh A.,etc.Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues[J].2016,64(5).
[16]Ya-Shu, Kuang,Sheng-Hui, Li,Yong, Guo,etc.Composition of gut microbiota in infants in China and global comparison.[J].2016,6(Spec ).
[17]Desbonnet L,Dinan TG,Garrett L,etc.The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.[J].2008,43(2).
[18]Shaoguang Wu,Patrice J. Morin,Djik Maouyo,etc.Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation[J].2003,124(2).
[19]Jonsson, Annika Lindskog,Backhed, Fredrik.Role of gut microbiota in atherosclerosis[J].2017,14(2).
[20]Elizabeth Elliott,Martha Douglas-Escobar,Josef Neu.Effect of Intestinal Microbial Ecology on the Developing Brain[J].2013,167(4).
[21]Ewaschuk, J,Endersby, R,Thiel, D,etc.Problotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis[J].2007,46(3).
[22]Antony Cougnoux,Guillaume Dalmasso,Ruben Martinez,etc.Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype[J].2014,63(12).
[23]Backhed F,Ding H,Wang T,etc.The gut microbiota as an environmental factor that regulates fat storage.[J].2004,101(44).
[24]Jiang, Z. D.,Ajami, N. J.,Petrosino, J. F.,etc.Randomised clinical trial: faecal microbiota transplantation for recurrent Clostridum difficile infection - fresh, or frozen, or lyophilised microbiota from a small pool of healthy donors delivered by colonoscopy[J].2017,45(7).
[25]Volker, Mai,Lisa H, Colbert,David, Berrigan,etc.Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms.[J].2003,63.
[26]Ye, Yang,Christian, Jobin.Microbial imbalance and intestinal pathologies: connections and contributions.[J].2014,7(10).
[27]A Venket, Rao,Alison C, Bested,Tracey M, Beaulne,etc.A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome.[J].2009,1(1).
[28]Olivia I, Coleman,Tiago, Nunes.Role of the Microbiota in Colorectal Cancer: Updates on Microbial Associations and Therapeutic Implications.[J].2016,(1).
[29]Ma, Yonghui,Liu, Jiayu,Rhodes, Catherine,etc.Ethical Issues in Fecal Microbiota Transplantation in Practice[J].2017,17(5).
[30]Keshteli, A. H.,Millan, B.,Madsen, K. L..Pretreatment with antibiotics may enhance the efficacy of fecal microbiota transplantation in ulcerative colitis: a meta-analysis[J].2017,10(2).
[31]Fei, N.,Zhao, L..An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice[J].2013,7(4).
[32]Xiang Jun, Shen,John F, Rawls,Thomas, Randall,etc.Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas.[J].1900,1.
[33]Vanessa K, Ridaura,Jeremiah J, Faith,Federico E, Rey,etc.Gut microbiota from twins discordant for obesity modulate metabolism in mice.[J].2013,341(6150).