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Natural killer cells inhibit pulmonary metastasis of hepatocellular carcinoma

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Journal Title:
World Chinese Journal of Digestology
Key Word:
自然杀伤细胞;侵袭;肝细胞肝癌;肺转移;白介素-2;Natural killer cells;Invasion;Hepatocellular carcinoma;Pulmonary metastasis;Interleukin-2

Abstract´╝Ü AIM To investigate the inhibitory role of natural killer (NK) cells in liver cancer metastasis.METHODS NK cells were isolated from human peripheral blood mononuclear cells,cultivated and identified.In vitro,NK cells were used to suppress liver cancer cell proliferation,migration and metastasis.In vivo,the homing of NK cells in the liver of nude mice was detected.A nude mouse orthotopic liver transplantation model was used to assess the role of NK cells in inhibiting the growth and metastasis of liver cancer in vivo.The expression of NKG2D,NKB1,perforin and granular enzyme was detected to assess the stimulatory effect of interleukin (IL)-2 on NK cell immune function.RESULTS In vitro,NK cells inhibited the proliferation,migration and invasion of liver cancer cells.In vivo,NK cells could survive in the liver of nude mice for a long time.NK cells significantly inhibit the pulmonary metastasis of liver cancer in nude mice.However,the liver tumor growth was not inhibited by NK cells.IL-2 can strengthen the suppressor function of NK cells in tumors.CONCLUSION The immunological function of NK cells can be strengthened by IL-2 to inhibit liver cancer metastasis.

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