Abstract: Non-alcoholic steatohepatitis (NASH),the more aggressive form of non-alcoholic fatty liver disease,may progress to cirrhosis and hepatocellular carcinoma.Only changes in diet and lifestyle are hard to maintain and have little effect in delaying the progression of NASH.Traditional methods are effective in reducing steatosis and inflammation,but they have no effect on fibrosis,which is the main determinant of patient outcome.With the understanding of the pathogenesis and progression of NASH,several promising novel therapies to target and possibly reverse fibrosis are being evaluated,making the future of NASH therapy more optimistic.