Abstract: Digestive system cancers are the most common malignant tumours.With the accelerated pace of modem life,the incidence of digestive system cancers is getting higher and the age of diagnosis tends to become younger.Attenuated Salmonella has anti-tumor characteristics,and it can also serve as a vector for gene therapy for tumors.In this paper,we will discuss the role of attenuated Salmonella in the treatment of liver cancer,gastric cancer,and colorectal cancer.