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New perspectives of CTLs related immunotherapy in treatment of liver cancer

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Journal Title:
World Chinese Journal of Digestology
Key Word:
原发性肝癌;细胞毒性T淋巴细胞;免疫反应;Hepatocellular carcinoma;Cytotoxic T lymphocytes;Immune reaction

Abstract´╝Ü Abnormal polypeptides produced during the processing of a variety of proteins in cancer cells are presented by major histocompatibility complex class Ⅰ molecules to stimulate tumor specific cytotoxic T lymphocytes (CTLs) to produce immune reactions to tumor.However,various factors in hepatocellular carcinoma inhibit the function of CTLs or result in a nonfunctional state.In recent years,great progress has been made on the research of how to reactivate and enhance the function of CTLs in liver cancer.In this paper,we review the recent advances in CTLs related immunotherapy with regard to its ability to enhance antigen presentation and directly induce immune responses.

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