Abstract: AIM To investigate the value of FibroScan and aspartate aminotransferase-to-platelet ratio index (APRI),alone or in combination,in predicting the risk of esophagogastric variceal bleeding in patients with liver cirrhosis.METHODS Two hundred and ten patients with posthepatitic cirrhosis were divided into a non-bleeding group (n =153) and a bleeding group (n =57) according to the presence of esophagogastric variceal bleeding or not.FibroScan values (LSM values) and APRI values were obtained within a week and compared between the two groups using t-tests.Receiver operating characteristic curve (ROC) analysis was used to assess the accuracy of LSM alone,APRI alone,and LSM + APRI in predicting the risk of esophagogastric variceal bleeding.RESULTS The LSM values of the patients with and without bleeding were 28.49 kPa ± 9.46 kPa and 22.87 kPa ± 6.95 kPa,respectively,and the APRI values were 2.99 ± 1.11 and 2.13 ± 1.01,respectively,both of which showed a significant difference between the two groups.The AUCs of LSM alone,APRI alone,and LSM + APRI in predicting the risk of bleeding were 0.669,0.727 and 0.722,respectively,suggesting that APRI alone and LSM + APRI had good diagnostic value in esophagogastric variceal bleeding.CONCLUSIONAPRI alone and FibroScan combined with APRI have good predictive value for the risk of esophageal variceal bleeding in patients with liver cirrhosis.