Abstract： With the development of social economy and the change in life style,the incidence of cardiovascular disease has obviously risen.Related risk factors include age,smoking,obesity,diabetes,hypertension and dyslipidemia.However,the etiology of certain cardiovascular diseases is largely unknown.In recent years,it has been found that Helicobacter pylori (H.pylori) infection is closely related to the occurrence and development of a variety of extra-gastrointestinal diseases.Many studies have explored the relationship between H.pylori infection and cardiovascular disease and suggested that H.pylori infection rate in patients with cardiovascular disease increases significantly.In addition,H.pylori eradication treatment is beneficial to the prevention of cardiovascular disease.However,there are still inconsistent results.In this paper,we will discuss the relationship between H.pylori infection and cardiovascular disease,highlighting the impact of H.pylori eradication on cardiovascular disease and the mechanism for H.pylori infection to induce cardiovascular disease.