Abstract： AIM To evaluate the preventive effect of early enteral nutrition combined with omeprazole on stress ulcer in patients with cerebral apoplexy.METHODS Fifty-two patients with cerebral apoplexy treated at our hospital from June 2013 to June 2016 were selected and randomly divided into a treatment group and a control group.The control group was given early enteral nutrition alone,and the treatment group was given early enteral nutrition combined with omeprazole.Gastric pH at 1 wk after treatment,length of hospital stay,bleeding time,stress ulcer incidence,mortality,and adverse reactions were compared between the two groups.RESULTS Compared with the control group,mean nocturnal gastric pH and 24-h mean gastric pH were significantly increased and the incidence rates of nocturnal gastric pH ＜ 4.0 and pH ＜ 4.0 significantly decreased (P ＜ 0.05);the length of hospital stay was significantly shorter;bleeding was significantly postponed;the incidence rates of stress ulcer and mortality were significantly decreased (P ＜ 0.05);and the percentages of patients with fecal occult blood and gastric occult blood were significantly decreased (P ＜ 0.05) in the observation group.There was no significant difference in the incidence of insomnia,headache,or abnormal liver function between the two groups (P ＞0.05).Before treatment,there was no significant difference in SAS score between the two groups (P ＞ 0.05);however,after treatment,SAS score was significantly lower in the observation group than in the control group (P ＜ 0.05).CONCLUSION Early enteral nutrition combined with omeprazole can effectively reduce the incidence of stress ulcer in patients with cerebral apoplexy.