Abstract： AIM To evaluate the clinical effects of nursing interventions in hepatitis B patients with a gallbladder stone attack.METHODS Seventy hepatitis B patients with a gallstone attack were randomly divided into a control group and an observation group,with 35 cases in each group.Both groups were given routine nursing care,and the observation group was additionally given nursing interventions consisting of diet nursing,psychological and emotional nursing,acupoint massage and auricular application.The anxiety and depression scores,pain score and satisfaction were compared between the two groups.RESULTS Compared with the values before intervention,both self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores were significantly lower after intervention in both groups (P ＜ 0.05),and SAS and SDS scores were significantly lower in the observation group than in the control group (P ＜ 0.05).VAS scores at 5 and 10 d after intervention were significantly lower than those before intervention in both groups (P ＜ 0.05),and VAS scores at 5 and 10 d after intervention were significantly better in the observation group than in the control group (P ＜ 0.05).The satisfaction rate was significantly higher in the observation group than in the control group (P ＜ 0.05).CONCLUSION Nursing interventions can reduce anxiety and depression,relieve pain and improve nursing satisfaction in hepatitis B patients with a gallstone attack.