Abstract: AIM To evaluate the clinical effects of Yinzhihuang injection in the treatment of patients with autoimmune hepatitis (AIH)and its effect on indexes of hepatic fibrosis.METHODSSeventy-four patients with AIH treated at our hospital between April 2013 and November 2015 were randomly divided into either a control group or an observation group,with 37 cases in each group.Both groups were given oral prednisone and azathioprine,and the observation group was additionally given Yinzhihuang injection.The clinical indicators,clinical curative effects and adverse reactions of the two groups were compared.RESULTS After treatment,serum alanine aminotransferase,aspartate transaminase,glutamyl transpeptidase,total bilirubin,glyoxalase and albumin in the observation group were significantly lower than those in the control group (t =5.056,8.186,7.254,3.959,2.928,and 2.460,respectively;P < 0.05);liver fiber indexes collagen Ⅳ,hyaluronan,procollagen Ⅲ peptide,and laminin in the observation group were significantly lower than those of the control group (t =8.043,12.692,4.85.8,and 8.683,respectively;P < 0.05);and the ratio of CD4+ Tcells/CD8+ T cells was significantly lower in the observation group than in the control group (t=2.708,P < 0.05).The total effective rate in the observation group (89.19%) was significantly higher than that of the control group (64.86%) (x2 =6.186,P =0.013).The overall incidence of adverse reactions in the observation group was significantly lower than that of the control group (5.41% vs 21.62%,x2 =4.163,P =0.041).CONCLUSION Yinzhihuang injection combined with Western medicine can significantly improve clinical efficacy and liver fiber indexes,and reduce adverse reactions in patients with AIH.