Abstract: AIM To evaluate the effect of heat-clearing and dampness-expelling therapy combined with rosuvastatin on biochemical indexes and physical fitness in patients with type 2 diabetes mellitus (T2DM).METHODS Eighty-six type 2 diabetic patients treated at our hospital from March 2015 to December 2015 were selected and randomly divided into a control group and an experimental group,with 43 cases in each group.Patients in the control group were treated with heat-clearing and dampness-expelling therapy alone,and the experimental group was treated with heatclearing and dampness-expelling therapy plus rosuvastatin.After 12 wk of treatment,blood biochemical indexes,physical indexes and adverse reactions of the two groups were compared.RESULTS After treatment,fasting blood glucose and triglyceride levels were significantly lower in the experimental group than in the control group (6.14 mmol/L ± 2.14 mmol/L vs 7.04mmol/L ± 2.15 mrnol/L,P < 0.05;0.16 mmol/L ±1.43 mmol/L vs 1.74 mrnol/L ± 0.23 mmol/L,P < 0.05);body fat percentage was significantly lower in the experimental group than in the control group (29.16 ± 4.29 vs 34.24 ± 4.52,P < 0.05).Patients in both groups showed no obvious adverse reactions such as allergy,nausea,vomiting,diarrhea,and muscle pain.CONCLUSION Heat-clearing and dampness-expelling therapy combined with rosuvastatin can reduce blood biochemical parameters and improve physical fitness in patients with T2DM,with no obvious adverse reactions.