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Role of cyclooxygenase-2 in immune response in liver fibrosis and mechanisms involved

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 8

DOI:: 10.11569/wcjd.v25.i8.702

Key Word:: 环氧合酶-2;肝纤维化;免疫;Cyclooxygenase-2;Liver fibrosis;Immunity

Abstract： Cyclooxygenase-2 (COX-2),an inducible enzyme,is almost not expressed in normal human and rat liver tissues,but is highly expressed in liver tissues of patients with chronic hepatitis and cirrhosis.Inhibition or interference of COX-2 expression can significantly inhibit the formation of hepatic fibrosis in rats,suggesting that COX-2 is involved in the occurrence and development of hepatic fibrosis;however,the underlying mechanism is unclear.Recent studies have shown that the role of COX-2 in the development of hepatic fibrosis may be related to immune response.In this paper,we review the role of COX-2 and its metabolites in the immune response in liver fibrosis,with an aim to provide a theoretical basis for clinical prevention and treatment of hepatic fibrosis.

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