Abstract: Duodenal stump fistula is a severe early postoperative complication of laparoscopic gastrectomy.It may cause the leakage of a large amount of digestive juices,which contain pancreatic juice and bile,into the abdominal cavity,thus leading to intra-abdominal hemorrhage and intra-abdominal infection,or even threatening the life.The most effective treatment for duodenal stump fistula is establishing effective and sufficient drainage as soon as possible.We recommend that effective operative treatment should be employed once duodenal stump fistula is diagnosed.After operation,Li's drainage tube is used for continuous drainage of the abdominal cavity.Proper antibiotics,symptomatic therapy,and effective nutrition support are the key to the treatment of duodenal stump fistula.If possible,a nasointestinal tube should be placed for enteral nutrition as soon as possible.In addition to these treatments,somatostatin and growth hormone can promote the healing of intestinal fistula.