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Paneth cells, antimicrobial peptides, and intestinal mucosal immunity

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 3

DOI:: 10.11569/wcjd.v25.i3.209

Key Word:: 潘氏细胞;α-防御素;抗微生物肽;固有免疫;肠道黏膜屏障;Paneth cells;α-defensins;Antimicrobial peptides;Innate immunity;Intestinal mucosal barrier

Abstract：潘氏细胞(Paneth cells,PCs)及其抗微生物肽(antimicrobial peptides,AMPs)与肠道微生物的生态学失衡、肠道炎症、全身感染等病理状况的发生密切相关.肠黏膜屏障与固有免疫功能的损害,常伴随着机体0-防御素等AMPs水平及其他炎症介质水平的改变.研究发现:PCs能在胆碱能兴奋剂、微生物及其抗原成分、肠内营养状态、遗传易感因素等因素的作用下,改变其本身的功能状态及效应分子的释放,诱发炎症性肠病、细菌移位、肠内细菌过度生长、自身免疫耐受损害等疾病及相关改变,对PCs的研究给临床治疗提供了新的靶点和策略.本文对近十年来人们对PCs、AMPs和肠道黏膜屏障及固有免疫之间关系的研究进展作一述评.

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