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DNA image cytometry for diagnosis of early gastric cancer

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 2

DOI:: 10.11569/wcjd.v25.i2.172

Key Word:: 胃癌;早期胃癌;DNA定量分析;DNA异倍体;研究进展;Gastric cancer;Early gastric cancer;DNA image cytometry;DNA aneuploidy;Research progress

Abstract：胃癌(gastric cancer,GC)是临床上最常见的恶性肿瘤之一,具有较高的发病率及病死率,早发现、早诊断、早治疗是提高疗效、延长患者生存年限的关键.目前,国内外采用细胞DNA肿瘤早期诊断技术用于多种常见肿瘤的辅助诊断,提高早期肿瘤的检出率.细胞恶变的过程中,DNA等遗传物质的改变早于细胞形态学的改变,因此可对细胞内的DNA进行定量分析,发现遗传物质异常的早期癌变细胞,进而较早发现GC,提高早期胃癌(early gastric cancer,EGC)的检出率,改善患者的治疗与预后.本文就DNA定量分析在EGC诊断中的应用及进展进行综述.

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