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Expression of BRG1 in colorectal cancer: Correlation with prognosis and MMP-2 expression
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- Author:
- No author available
- Journal Title:
- World Chinese Journal of Digestology
- Issue:
- 35
- DOI:
- 10.11569/wcjd.v24.i35.4691
- Key Word:
- 结直肠癌;BRG1;基质金属蛋白酶-2;预后;Colorectal cancer;BRG1;Matrix metalloproteinase-2;Prognosis
Abstract： 目的 分析结直肠癌组织中BRG1表达与结直肠癌临床病理特征及预后的关系,并初步探讨其机制.方法 应用组织芯片及免疫组织化学方法检测112例结直肠癌组织和71例正常肠黏膜组织中BRG1及基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)蛋白的表达,统计学分析BRG1表达与临床病理特征及患者预后的关系,并分析其与MMP-2表达的相关性.结果 (1)BRG1和MMP-2在结直肠癌组织中的阳性率分别为66.1％和61.2％,较正常肠黏膜组织35.2％和3.3％明显增高(P＜0.01);(2)结直肠癌组织中BRG1高表达与结直肠癌患者临床病理特征包括患者性别、年龄、肿瘤大小、浸润深度、分化程度、淋巴结转移及临床分期之间均没有显著意义,但与患者5年总体生存率呈明显负相关,BRG1表达越高,患者预后越差;(3)结直肠癌组织中BRG1的表达与MMP-2呈正相关(r=0.307,P＜0.05).结论 BRG1在结直肠癌组织中表达增高,可能成为结直肠癌患者的独立预后因子,原因可能与促进MMP-2异常表达有关.
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