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Value of liver function test for prediction of asymptomatic common bile duct stones in patients with cholecystolithiasis
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- Author:
- No author available
- Journal Title:
- World Chinese Journal of Digestology
- Issue:
- 31
- DOI:
- 10.11569/wcjd.v24.i31.4293
- Key Word:
- 胆囊结石;胆总管结石;肝功能;γ-谷氨酰基转移酶;诊断;Choledocholithiasis;Cholecystolithiasis;Liver function;γ-glutamyltransferase;Diagnosis
Abstract： 目的 探讨血清肝功能指标异常对胆囊结石合并无症状胆总管结石的预判价值.方法 回顾性分析金华市中心医院2012-01/2016-01收治的398例胆囊结石患者的临床资料.根据是否合并无症状胆总管结石,分为胆囊结石合并无症状胆总管结石组(简称胆总管结石组)和单纯胆囊结石组(简称胆囊结石组),比较两组患者的肝功能指标情况,评估肝功能指标异常对无症状胆总管结石的预判价值.结果 胆总管结石组与胆囊结石组血清谷丙转氨酶、谷草转氨酶、总胆红素及直接胆红素的比较,差异无统计学意义(P＞0.05).胆总管结石组和胆囊结石组血清γ-谷氨酰转肽酶(gamma-glutamyl transpeptidase,GGT)分别为(150.89U/L±40.95 U/L vs 36.58 U/L±11.28 U/L),碱性磷酸酶(alkaline phosphatase,ALP)分别为(142.83 U/L±21.99 U/L vs120.96 U/L±20.27 U/L),差异有统计学意义(P＜0.05).ROC曲线分析显示血清GGT、ALP对应曲线下面积分别为0.914、0.569,诊断准确度最高的临界值分别为89.5 U/L、136 U/L,敏感度分别为89.9％、45.8％,特异度分别为91.8％、71.9％.结论 血清GGT的异常升高对胆囊结石合并无症状胆总管结石有较大的预判价值.
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