Paper - WANFANG MED ONLINE

You Position: Home > Paper

Clinical significance of expression of high mobility group protein B1 and Toll-like receptor 4 in esophageal squamous cell carcinoma

( views:41, downloads:0 )

Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 23

DOI:: 10.11569/wcjd.v24.i23.3495

Key Word:: 高迁移率族蛋白B1;Toll样受体4;食管鳞癌;High mobility group protein B1;Toll-like receptor 4;Esophageal squamous cell carcinomas

Abstract：目的:探讨高迁移率族蛋白B1 (high mobility group protein B1,HMGBl)和Toll样受体4(Toll-like receptor 4,TLR4)在人食管鳞状细胞癌(食管鳞癌)组织中的表达及其临床意义.方法:选择72例食管鳞癌标本,15例癌旁正常组织标本,采用EnVision免疫组织化学染色法检测HMGB1和TLR4在食管鳞癌组织及癌旁正常组织中的表达,并应用统计学方法对其表达与临床病理因素进行分析.结果:食管鳞癌组织中HMGB1、TLR4的表达显著高于正常组织(P＜0.05),且与淋巴结转移及TNM分期相关(P＜0.05),与肿瘤大小、分化程度等无相关性.食管麟癌组织HMGB1和TLR4的表达呈显著正相关(r=0.377,P＜0.01).结论:食管鳞癌组织中HMGB1、TLR4的表达显著高于癌旁正常组织,且其表达与淋巴结转移及TNM分期相关,联合检测二者可能有助于评估食管鳞癌的恶性程度.因此,HMGBl/TLR信号通路有可能作为反映食管癌预后的重要生物学指标及抗食管癌的重要靶点.

Reference

[1]Furong, Liu,Yaojun, Zhang,Zhenwei, Peng,etc.High expression of high mobility group box 1 (hmgb1) predicts poor prognosis for hepatocellular carcinoma after curative hepatectomy.[J].2012,10.
[2]Md A Nahid,Minoru Satoh,Edward KL Chan.MicroRNA in TLR signaling and endotoxin tolerance[J].2011,(5).
[3]Han,B.-S.,Cui,L.,Huang,F.,etc.Expression and clinical significance of HMGB1 in human liver cancer: Knockdown inhibits tumor growth and metastasis in vitro and in vivo[J].2013,29(1).
[4]Guoqiang, Bao,Qing, Qiao,Huadong, Zhao,etc.Prognostic value of HMGB1 overexpression in resectable gastric adenocarcinomas.[J].2010,8.
[5]Kuper H,Adami HO,Trichopoulos D.Infections as a major preventable cause of human cancer.[J].2000,248(3).
[6]Daniel Droemann,Dirk Albrecht,Johannes Gerdes,etc.Human lung cancer cells express functionally active Toll-like receptor 9[J].2005,6(1).
[7]Munirathinam, Gnanasekar,Ramaswamy, Kalyanasundaram,Guoxing, Zheng,etc.HMGB1: A Promising Therapeutic Target for Prostate Cancer.[J].2013,2013.
[8]Kono K,Sugai H,Kawaguchi Y,etc.Expression of high mobility group box chromosomal protein-1 (HMGB-1) in gastric cancer.[J].2007,27(1A).
[9]Park,M.,Kim,Y.G.,Shin,J.-S.,etc.High mobility group box-1 is phosphorylated by protein kinase C zeta and secreted in colon cancer cells[J].2012,424(2).
[10]Zeh HJ 3rd,Lotze MT,Tang D,etc.High-mobility group box 1 and cancer.[J].2010,1799(1).
[11]Shijun, Wang,Christoph, Schmaderer,Eva, Kiss,etc.Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling.[J].1900,3(1-2).
[12]Liu CT,Fan W,Jia CQ,etc.Serum high mobility group box chromosomal protein 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma.[J].2008,40(6).
[13]Michael G, Kelly,Ayesha B, Alvero,Rui, Chen,etc.TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer.[J].2006,66.
[14]Hanna, Lee,Meiying, Song,Nara, Shin,etc.Diagnostic significance of serum HMGB1 in colorectal carcinomas.[J].2012,7(4).
[15]Kleeberger SR,Malkinson AM,Walker CR,etc.Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis.[J].2005,97(23).
[16]Rui, Kang,Daolin, Tang.Autophagy in pancreatic cancer pathogenesis and treatment.[J].2012,2(4).
[17]Jang,S.,Park,K.H.,Song,S.Y.,etc.Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma[J].2012,103(9).
[18]Takumi, Takeuchi,Koichi, Sakazume,Akiko, Tonooka,etc.Cytosolic HMGB1 expression in human renal clear cell cancer indicates higher pathological T classifications and tumor grades.[J].2013,10(3).
[19]Kang,J.-W.,Lee,S.-M.,Koh,E.-J..Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway[J].2011,50(4).
[20]Sporn MB,Albini A.The tumour microenvironment as a target for chemoprevention.[J].2007,7(2).
[21]Frances Balkwill,Antonio Sica,Paola Allavena,etc.Cancer-related inflammation[J].2008,454(7203).
[22]Monga,S.P.,Yan,W.,Liang,X.,etc.High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases[J].2012,55(6).
[23]Hye Won, Chung,Sang-Guk, Lee,Heejung, Kim,etc.Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer.[J].2009,7.