Paper - WANFANG MED ONLINE

You Position: Home > Paper

Gut-liver axis: An important target for prevention and treatment of liver diseases

( views:20, downloads:0 )

Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 23

DOI:: 10.11569/wcjd.v24.i23.3454

Key Word:: 肠道菌群;肠-肝轴;慢性肝病;预防和治疗;Intestinal microbiome;Gut-liver axis;Chronic liver disease;Prevention and treatment

Abstract：人体肠道内寄居着一个复杂、多样化的微生物群落,促进与其共生关系的宿主的新陈代谢和消化.肝病与肠道菌群的定性(失调)和定量(过度生长)改变密切相关.外在因素如饮食、酒精等,可促进肠道菌群失调.在动物模型中,菌群失调可引起肠道炎症、肠屏障破坏以及细菌性产物移位,进而加剧肝损伤和炎症.在失调的肠道环境中产生的细菌性产物和宿主因素在肝病发病机制中同样重要.本文就肠-肝轴失调在非酒精性脂肪性肝病、酒精性肝病以及肝硬化进展中的作用的研究进展和恢复肠道稳态在肝病防治中的潜在应用价值进行简要综述.

Reference

[1]Vito Racanelli,Barbara Rehermann.The liver as an immunological organ[J].2006,43(S1).
[2]Leung,T.-M.,Nieto,N..CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease[J].2013,58(2).
[4]Zongxin, Ling,Xia, Liu,Yiwen, Cheng,etc.Decreased Diversity of the Oral Microbiota of Patients with Hepatitis B Virus-Induced Chronic Liver Disease: A Pilot Project.[J].2015,5.
[5]Els van Nood,Anne Vrieze,Max Nieuwdorp,etc.Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile[J].2013,368(5).
[6]Bajaj,J.S.,Hylemon,P.B.,Ridlon,J.M.,etc.Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation[J].2012,303(3 Pt.1).
[7]Bajaj,J.S.,Ridlon,J.M.,Hylemon,P.B.,etc.Linkage of gut microbiome with cognition in hepatic encephalopathy[J].2012,302(1 Pt.1).
[8]Bajaj, Jasmohan S.,Heuman, Douglas M.,Hylemon, Phillip B.,etc.Altered profile of human gut microbiome is associated with cirrhosis and its complications[J].2014,60(5).
[9]Turnbaugh PJ,Ley RE,Mahowald MA,etc.An obesity-associated gut microbiome with increased capacity for energy harvest[J].2006,444(7122).
[10]Arthur W Yan,Bernd Schnabl.Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease[J].2012,(4).
[11]Rahul, Rai,Vivek A, Saraswat,Radha K, Dhiman.Gut microbiota: its role in hepatic encephalopathy.[J].2015,5(Suppl 1).
[12]T M, Bauer,B, Steinbrückner,F E, Brinkmann,etc.Small intestinal bacterial overgrowth in patients with cirrhosis: prevalence and relation with spontaneous bacterial peritonitis.[J].2001,96(10).
[13]Tilman M Bauer,Henning Schwacha,Bernhard Steinbrückner,etc.Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia[J].2002,97(9).
[14]Min Xu,Baohong Wang,Yiqi Fu,etc.Changes of Fecal Bifidobacterium Species in Adult Patients with Hepatitis B Virus-Induced Chronic Liver Disease[J].2012,63(2).
[15]Forsyth CB,Voigt RM,Shaikh M,etc.Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability.[J].2013,305(1 Pt.1).
[16]Chi-Sen Chang,Gran-Hum Chen,Han-Chung Lien,etc.Small intestine dysmotility and bacterial overgrowth in cirrhotic patients with spontaneous bacterial peritonitis[J].1998,28(5).
[17]Marshall John C.The gut as a potential trigger of exercise-induced inflammatory responses[J].1998.
[18]Szabo, Gyongyi.Gut-Liver Axis in Alcoholic Liver Disease[J].2015,148(1).
[19]Xie, G.,Li, Q.,Qiu, Y.,etc.Chronic ethanol consumption alters mammalian gastrointestinal content metabolites[J].2013,12(7).
[20]Hartmann,P.,Chen,P.,Wang,H.J.,etc.Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice[J].2013,58(1).
[21]Day,CP,James,OF.Steatohepatitis: a tale of two "hits"? (editorial)[J].1998,114(4).
[22]Bevins,C.L.,Schoelmerich,J.,Stange,E.F.,etc.Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense[J].2012,55(4).
[23]Yang F,Li L,Lu H,etc.Characterization of fecal microbial communities in patients with liver cirrhosis.[J].2011,54(2).
[24]T, Poynard,V, Ratziu,Y, Benhamou,etc.Natural history of HCV infection.[J].2000,14(2).
[25]Fatiha Nassir,Jamal A Ibdah.Role of mitochondria in alcoholic liver disease[J].2014,(9).
[26]Weiwei, Jiang,Na, Wu,Xuemei, Wang,etc.Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease.[J].2015,5.
[27]Jasmohan S, Bajaj,Douglas M, Heuman,Arun J, Sanyal,etc.Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy.[J].2013,8(4).
[28]Nur Arslan.Obesity, fatty liver disease and intestinal microbiota[J].2014,(44).
[29]E, Lau,D, Carvalho,P, Freitas.Gut Microbiota: Association with NAFLD and Metabolic Disturbances.[J].2015,2015.
[30]DeMinicis,S.,Rychlicki,C.,Agostinelli,L.,etc.Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice[J].2014,59(5).
[31]Bajaj,J.S.,Heuman,D.M.,Hylemon,P.B.,etc.Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis[J].2014,39(10).
[32]Yan AW,Brandl J,Tsukamoto H,etc.Enteric dysbiosis associated with a mouse model of alcoholic liver disease.[J].2011,53(1).
[33]Backhed F,Ding H,Wang T,etc.The gut microbiota as an environmental factor that regulates fat storage.[J].2004,101(44).
[34]Kouichi Miura,Hirohide Ohnishi.Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease[J].2014,(23).
[35]Silvia M, Ferolla,Geyza N A, Armiliato,Cláudia A, Couto,etc.The role of intestinal bacteria overgrowth in obesity-related nonalcoholic fatty liver disease.[J].2014,6(12).