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Strategies to prevent mother-to-child transmission of hepatitis B

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 23

DOI:: 10.11569/wcjd.v24.i23.3439

Key Word:: 乙型肝炎病毒;母婴传播;抗病毒药物;Hepatitis B virus;Mother-to-child transmission;Antiviral agents

Abstract：母婴传播是乙型肝炎病毒(hepatitis B virus,HBV)感染的主要传播方式,阻断母婴传播是控制乙型肝炎流行的重要手段.然而目前妊娠期乙型肝炎管理尚存在诸多问题,如缺乏有关母婴乙型肝炎诊治的统一指南策略等,尽管目前我国对新生儿采取注射乙型肝炎免疫球蛋白和乙型肝炎疫苗的主-被动联合免疫来阻断母婴传播,但仍有新生儿感染HBV.近年来随着抗HBV药物的使用,人们积累了核苷类药物阻断乙型肝炎母婴传播的成功经验.本文系统总结分析了目前用于阻断HBV母婴传播的各种方案,旨在使母婴传播的阻断策略更加规范有效.

Reference

[1]王慧华,王正平.联合免疫婴儿的娩出方式对乙型肝炎病毒母婴传播影响的Meta分析[J].2010,(3).
[2]张雪峰.乙型肝炎病毒母婴传播阻断策略[J].2014,(14).
[3]彭劼,侯金林.妊娠与抗乙型肝炎病毒治疗的现状与管理[J].2011,(3).
[4]孙维会,马磊,郝岸华,等.替比夫定阻断乙型肝炎病毒母婴传播的效果与安全性评价[J].2015,(3).
[5]周岳进,郑金莉,潘华将,等.替比夫定治疗妊娠慢性乙型肝炎患者生育子女远期疗效与安全性[J].2014,(8).
[6]韩国荣,江红秀,王根菊,等.替比夫定对乙型肝炎病毒高载量孕妇母婴传播的阻断效果及其安全性[J].2012,(3).
[7]陈川英,涂相林,程全红,等.慢性乙型肝炎患者妊娠早期替比夫定抗病毒的疗效及母婴阻断的临床观察[J].2015,(1).
[8]窦晓光,丁洋,盛秋菊.乙型肝炎病毒携带孕妇口服核苷（酸）类似物阻断其母婴传播共识与挑战[J].2012,(2).
[9]韩国荣,丁祎.慢性乙型肝炎育龄妇女及孕妇的抗病毒治疗指征与时机的选择[J].2015,(11).
[10]蒋小仙,黄文豹,吴旻,等.妊娠中期慢性乙型肝炎抗病毒治疗的疗效及安全性分析[J].2015,(3).
[11]Ji,Y.,Jiang,Q.,Yu,M.,etc.The efficacy and safety of antiviral therapy with lamivudine to stop the vertical transmission of hepatitis B virus[J].2012,31(9).
[12]Wang CM,Bai SF,Zhao W,etc.A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection.[J].2011,55(6).
[13]Rajbhandari, R.,Barton, K.,Juncadella, A. C.,etc.Discontinuity of care for mothers with chronic hepatitis B diagnosed during pregnancy[J].2016,23(7).
[14]Hakim, J.,Chidziva, E.,Zalwango, E.,etc.Pregnancy and infant outcomes among HIV-infected women taking long-term art with and without tenofovir in the DART trial[J].2012,9(5).
[15]Liu,M.,Cai,H.,Yi,W..Safety of telbivudine treatment for chronic hepatitis B for the entire pregnancy[J].2013,20(Suppl.1).
[16]Xiangru Chen,Jie Chen,Jian Wen,etc.Breastfeeding Is Not a Risk Factor for Mother-to-Child Transmission of Hepatitis B Virus.[J].2013,8(1).
[17]Tram T, Tran.Management of hepatitis B in pregnancy: weighing the options.[J].2009,76 Suppl 3.
[18]Yali, Hu,Xinwei, Dai,Yi-Hua, Zhou,etc.A knowledge survey of obstetrics and gynecology staff on the prevention of mother-to-child transmission of hepatitis B virus.[J].2013,7(5).
[19]Nancy, Leung.Chronic hepatitis B in Asian women of childbearing age.[J].2009,3.
[20]Yali, Hu,Jie, Chen,Jian, Wen,etc.Effect of elective cesarean section on the risk of mother-to-child transmission of hepatitis B virus.[J].2013,13.
[21]Yang, Y. -F.,Han, G. -R.,Jiang, H. -X.,etc.Efficacy and safety of telbivudine treatment: an open-label, prospective study in pregnant women for the prevention of perinatal transmission of hepatitis B virus infection[J].2015,22(9).
[22]Wang,L.,Kourtis,A.P.,Ellington,S.,etc.Safety of tenofovir during pregnancy for the mother and fetus: A systematic review[J].2013,57(12).
[23]Zhao Zhang,Chao CHEN,Zhe Li,etc.Individualized management of pregnant women with high hepatitis B virus DNA levels[J].2014,(34).
[24]Y, Bacq,C, Gaudy-Graffin,S, Marchand.[Prophylaxis of mother-to-infant transmission of hepatitis B virus].[J].2015,22(4).
[25]Xiaofeng Liang,Shengli Bi,Weizhong Yang,etc.Reprint of: Epidemiological serosurvey of Hepatitis B in China-Declining HBV prevalence due to Hepatitis B vaccination[J].2013,31.
[26]Yi, Panpan,Chen, Ruochan,Huang, Yan,etc.Management of mother-to-child transmission of hepatitis B virus: Propositions and challenges[J].2016,77.
[27]Natalie H. Bzowej.Optimal Management of the Hepatitis B Patient Who Desires Pregnancy or Is Pregnant[J].2012,11(2).
[28]H. Zou,Y. Chen,Z. Duan,etc.Virologic factors associated with failure to passive-active immunoprophylaxis in infants born to HBsAg-positive mothers[J].2012,19(2).
[29]Zhang,H.,Pan,C.Q.,Pang,Q.,etc.Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real-life practice[J].2014,60(2).
[30]Tsai, Naoky,Bartholomew, Marguerite Lisa,Yamada, Seiji,etc.Use of Tenofovir Disoproxil Fumarate in Highly Viremic, Hepatitis B Mono-Infected Pregnant Women[J].2014,59(11).
[31]Henry Lik Yuen Chan,Jia-Horne Kao,Teerha Piratvisuth,etc.Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update[J].2012,6(3).
[32][Noauthornameavailable].EASL clinical practice guidelines: Management of chronic hepatitis B virus infection[J].2012,57(1).