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Role of B7-H1 in gastrointestinal cancer

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 20

DOI:: 10.11569/wcjd.v24.i20.3135

Key Word:: B7-H1;免疫逃逸;胃肠道肿瘤;B7-H1;Immune evasion;Gastrointestinal cancer

Abstract：恶性肿瘤发生发展过程中会产生突变蛋白,可作为抗原而被免疫系统识别.然而机体往往难以产生有效控制肿瘤的免疫反应,即形成所谓肿瘤的免疫逃逸状态.B7-H1是表达在免疫和肿瘤细胞中的B7家族分子,被发现是维持免疫逃逸的重要机制.B7-H1作为共刺激分子,能够在T细胞免疫起始和效应阶段下调抗肿瘤免疫反应;又参与调节肿瘤细胞自身增殖、凋亡和侵袭等生物学行为.阻断B7-H1,在临床前肿瘤模型和临床试验中显现出巨大的抗肿瘤效应.B7-Hl阻断可能为胃肠道肿瘤提供新的治疗途径.本文就B7-Hl参与肿瘤免疫逃逸的机制及在胃肠道肿瘤中的研究进展作一综述.

Reference

[1]Keir ME,Freeman GJ,Sharpe AH,etc.Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses.[J].2007,27(1).
[2]Ott,P.A.,Hodi,F.S.,Robert,C..CTLA-4 and PD-1/PD-L1 blockade: New immunotherapeutic modalities with durable clinical benefit in melanoma patients[J].2013,19(19).
[3]Kuchroo VK,Sharpe AH,Latchman YE,etc.PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.[J].2004,101(29).
[4]Fumiya, Hirano,Katsumi, Kaneko,Hideto, Tamura,etc.Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.[J].2005,65.
[5]Katarzyna, Karwacz,Christopher, Bricogne,Douglas, MacDonald,etc.PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells.[J].2011,3(10).
[6]Legat A,Baitsch L,Devevre E,etc.Exhaustion of tumor-specific CD8 T cells in metastases from melanoma patients.[J].2011,121(6).
[7]Vacchelli E,Vitale I,Eggermont A,etc.Trial watch: Dendritic cell-based interventions for cancer therapy.[J].2013,2(10).
[8]John C Riches,Jeffrey K Davies,Fabienne McClanahan,etc.T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.[J].2013,121(9).
[9]Song,S.,Yuan,P.,Wu,H.,etc.Dendritic cells with an increased PD-L1 by TGF-β induce T cell anergy for the cytotoxicity of hepatocellular carcinoma cells[J].2014,20(1).
[10]Nishimura H,Honjo T.PD-1: an inhibitory immunoreceptor involved in peripheral tolerance.[J].2001,22(5).
[11]Shi, Sheng-Jia,Wang, Li-Juan,Wang, Guo-Dong,etc.B7-H1 Expression Is Associated with Poor Prognosis in Colorectal Carcinoma and Regulates the Proliferation and Invasion of HCT116 Colorectal Cancer Cells.[J].2013,8(10).
[12]Shuo, Wang,Yonghua, Wang,Jing, Liu,etc.Silencing B7-H1 enhances the anti-tumor effect of bladder cancer antigen-loaded dendritic cell vaccine in vitro.[J].2014,7.
[13]Zou W,Chen L.Inhibitory B7-family molecules in the tumour microenvironment.[J].2008,8(6).
[14]Erin Jou,Lakshmi Rajdev.Current and emerging therapies in unresectable and recurrent gastric cancer[J].2016,(20).
[15]Herbst, Roy S.,Soria, Jean-Charles,Kowanetz, Marcin,etc.Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients[J].2014,515(Nov.27 TN.7528).
[16]Chen, Nan,Fang, Wenfeng,Zhan, Jianhua,etc.Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation[J].2015,10(6).
[17]Xiao, Yanping,Freeman, Gordon J..The Microsatellite Instable Subset of Colorectal Cancer Is a Particularly Good Candidate for Checkpoint Blockade Immunotherapy[J].2015,5(1).
[18]Le, D. T.,Uram, J. N.,Wang, H.,etc.PD-1 Blockade in Tumors with Mismatch-Repair Deficiency[J].2015,372(26).
[19]Lote, Hazel,Cafferkey, Catherine,Chau, Ian.PD-1 and PD-L1 blockade in gastrointestinal malignancies[J].2015,41(10).
[20]Wang, L,Pino-Lagos, K,de Vries, VC,etc.Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3(+)CD4(+) regulatory T cells[J].2008,105(27).
[21]Fousek, Kristen,Ahmed, Nabil.The Evolution of T-cell Therapies for Solid Malignancies[J].2015,21(15).
[22]H, Dong,G, Zhu,K, Tamada,etc.B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.[J].1999,5(12).
[23]Dong H,Tamura H,Tamada K,etc.Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.[J].2002,8(8).
[24]Fan, Wang,Jun, Ma,Junwei, Liu,etc.Synthetic small peptides acting on B7H1 enhance apoptosis in pancreatic cancer cells.[J].2012,6(3).
[25]Hanahan, D.,Weinberg, R.A..Hallmarks of cancer: The next generation[J].2011,144(5).
[26]Song, Xiao,Liu, Junwei,Lu, Yi,etc.Overexpression of B7-H1 correlates with malignant cell proliferation in pancreatic cancer[J].2014,31(3).
[27]Padmanee, Sharma,James P, Allison.The future of immune checkpoint therapy.[J].2015,348(6230).
[28]Harris KJ,Liu X,Dong H,etc.B7-h1 expressed by activated CD8 T cells is essential for their survival.[J].2011,187(11).
[29]Azuma T,Yao S,Zhu G,etc.B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.[J].2008,111(7).
[30]de Mestier, Louis,Lardiere-Deguelte, Sophie,Volet, Julien,etc.Recent insights in the therapeutic management of patients with gastric cancer[J].2016,48(9).
[31]Yiwei, Wang,Hang, Wang,Qi, Zhao,etc.PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma.[J].2015,32(8).