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Relationship between serum CA199 levels and blood glucose control in patients with type 2 diabetes

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Author:
No author available
Journal Title:
World Chinese Journal of Digestology
Issue:
19
DOI:
10.11569/wcjd.v24.i19.3064
Key Word:
2型糖尿病;糖链抗原199;血糖;Type 2 diabetes;Carbohydrate antigen 199;Blood sugar

Abstract´╝Ü 目的:分析2型糖尿病患者血清糖链抗原199(carbohydrate antigen 199,CA199)水平与血糖控制的相关性.方法:测定77例住院2型糖尿病患者血清CA199水平,分别根据糖化血红蛋白、空腹血糖、餐后2h血糖水平将糖尿病患者分为低糖化组、高糖化组、空腹血糖达标组、高空腹血糖组、餐后血糖达标组及餐后高血糖组.比较各组CA199水平;分别计算糖化血红蛋白、空腹血糖、餐后2h时血糖、年龄、病程、体质量指数、总胆固醇、甘油三酯、高密度脂蛋白胆固醇,低密度脂蛋白胆固醇与CA199的相关性并进行多元Logistic回归分析,比较各变量与CA199的相关程度.结果:高HbA1c患者的CA199水平为15.77U/mL(10.15-26.34 U/mL)显著高于低HbA1c的10.23 U/mL(6.34-15.34 U/mL)(Z=-3.455,P<0.05),高空腹血糖组血清CA199水平14.34U/mL(9.35-26.38 U/mL)也高于正常空腹血糖组的13.17 U/mL(9.38-24.58 U/mL)(Z=-2.348,P<0.05).高餐后血糖组血清和正常餐后血糖组血清CA199水平比较无统计学差异(Z=-0.183,P>0.05).Spearman相关分析显示,CA199与糖化血红蛋白(r=0.234,P=0.001)、空腹血糖(r=0.245,P<0.001)呈正相关(r=0.534,p=0.001),与餐后2h血糖、胰岛素抵抗及胰岛B细胞功能无相关性.结论:2型糖尿病患者血清CA199水平与糖化血红蛋白及空腹血糖成正相关,与餐后2小时血糖无明显相关性.

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