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Clinical features and prognosis of serum α-fetoprotein positive advanced gastric cancer
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- Author:
- No author available
- Journal Title:
- World Chinese Journal of Digestology
- Issue:
- 17
- DOI:
- 10.11569/wcjd.v24.i17.2708
- Key Word:
- 胃肿瘤;甲胎蛋白;预后;Gastric cancer;α-fetoprotein;Prognosis
Abstract： 目的:观察血清甲胎蛋白(α-fetoprotein,AFP)阳性晚期胃癌患者的临床特征及预后.方法:回顾收集江苏省宜兴市人民医院收治的46例血清AFP阳性晚期胃癌患者作为研究组,并选取同期收治的85例血清AFP阴性晚期胃癌患者作为对照组,分析两组患者的病例资料、化疗方案等,随访两组患者生存时间.结果:与对照组比较,研究组肿瘤恶性程度明显增高(P=0.014),术后病理分期明显偏晚(P=0.045),肝转移发生率明显增高(P=0.001).研究组中位无进展生存时间(progress-free survival,PFS)明显短于对照组(4.5 mo vs 6.4 mo,P＜0.01),研究组的1年生存率略低于对照组(41.3％ vs 52.9％,P=0.203),无统计学意义,Kaplan-Meier生存曲线提示研究组中位生存时间较对照组明显缩短(10.8 mo vs 12.6 mo,尸=0.016),差异有统计学意义.结论:血清AFP阳性晚期胃癌是一种特殊的肿瘤类型,恶性程度高,容易引起肝转移,化疗效果差,预后差.血清AFP水平异常升高可作为判断胃癌预后差的敏感指标.
- [1]常彬霞,辛绍杰.甲胎蛋白及其临床应用研究进展[J].2010,(6).
- [2]解春生,郭海,沙素娟,等.肿瘤标志物对消化系统恶性肿瘤诊断价值的初探[J].2000,(z1).
- [3]温世军,刘忠,胡祥.血清甲胎蛋白阳性胃癌患者的临床特点及预后分析[J].2016,(1).
- [4]茅翔,罗奋,陈宗祐,等.提高对胃肝样腺癌和产甲胎蛋白胃癌的认识[J].2015,(6).
- [5]Sumei, Lu,Yongmei, Ma,Tao, Sun,etc.Expression of α-fetoprotein in gastric cancer AGS cells contributes to invasion and metastasis by influencing anoikis sensitivity.[J].2016.
- [6]El Bahrawy M.Alpha-fetoprotein-producing non-germ cell tumours of the female genital tract.[J].2010,46(8).
- [7]Dong Hoon, Lew,Woon Tae, Jung,Hong Jun, Kim,etc.[Clinicopathological characteristics and prognosis of alpha-fetoprotein producing gastric cancer].[J].2013,62(6).
- [8]Xiao-Dong, Li,Chang-Ping, Wu,Mei, Ji,etc.Characteristic analysis of α-fetoprotein-producing gastric carcinoma in China.[J].2013,11(1).
- [9]YU FANG,LIN WANG.Successful multimodal therapy for an α-fetoprotein-producing gastric cancer patient with simultaneous liver metastases.[J].2015,10(5).
- [10]Kono K,Amemiya H,Sekikawa T,etc.Clinicopathologic features of gastric cancers producing alpha-fetoprotein.[J].2002,19(5).
- [11]Daguang, Wang,Chunping, Li,Yuechao, Xu,etc.Clinicopathological characteristics and prognosis of alpha-fetoprotein positive gastric cancer in Chinese patients.[J].2015,8(6).
- [12]Liu,X.,Yu,H.,Cai,H.,etc.Expression of CD24, p21, p53, and c-myc in alpha-fetoprotein-producing gastric cancer: Correlation with clinicopathologic characteristics and survival[J].2014,109(8).
- [13]Ali Murat, Tatli,Zuhat, Urakci,Mehmet Emin, Kalender,etc.Alpha-fetoprotein (AFP) elevation gastric adenocarcinoma and importance of AFP change in tumor response evaluation.[J].2015,16.
- [14]He, Qingsi,Jian, Mi,Qu, Hui,etc.High level of serum AFP is an independent negative prognostic factor in gastric cancer[J].2015,30(4).