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Correlation between coronary atherosclerotic heart disease and Helicobacter pylori infection
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- Author:
- No author available
- Journal Title:
- World Chinese Journal of Digestology
- Issue:
- 10
- DOI:
- 10.11569/wcjd.v24.i10.1613
- Key Word:
- 冠状动脉粥样硬化性心脏病;幽门螺杆菌;同型半胱氨酸;14C-尿素呼气试验;Coronary atherosclerotic heart disease;Helicobacter pylori;Homocysteine;14C-urea breath
Abstract： 目的:了解幽门螺杆菌(Helicobacter pylori,H.pylori)感染与冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease,CAHD)的相关性.方法:对吉林大学第四医院心内科就诊并明确诊断为CAHD的1030例病例和同期体检中心非CAHD的受检者1116例行14C-尿素呼气试验检查,比较两组H.pylori阳性率.CAHD组根据H.pylori检测结果分成H.pylori阳性组和H.pylori阴性组,分析两组患者的血清同型半胱氨酸水平的差别.根据SYNTAX评分将CAHD患者分为低危组、中危组、高危组,分析各组患者H.pylori阳性率的差异,H.pylori阳性的CAHD患者进一步分析各危险组的血清同型半胱氨酸水平差异.结果:CAHD患者H.pylori的阳性率高于体检组,差异有统计学意义(P＜0.01).CAHD患者中H.pylori阳性组血清同型半胱氨酸浓度高于阴性组,差异有统计学意义(P＜0.01).高危组CAHD患者的H.pylori阳性率最高,其次是中危组,低危组阳性率最低,但差异无统计学意义(P＞0.05).H.pylori阳性的CAHD患者随着危险度增加其血清同型半胱氨酸浓度也增加,各组间比较差异有统计学意义(P＜0.01).结论:H.pylori感染很可能是CAHD的重要危险因素,H.pylori感染可能通过升高血清同型半胱氨酸水平来增加冠.状动脉损害程度,从而促进冠状动脉粥样硬化的发生和发展,有待于进一步探讨.
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