Abstract： AIM: To evaluate the effects of humanistic intervention in patients with functional dyspepsia with depression.METHODS: One hundred patients with functional dyspepsia with depression treated at our hospital were randomly divided into a control group and a study group, with 50 cases in each group.The control group received routine nursing care, and the study group received humanistic nursing intervention on the basis of routine nursing.Depression and anxiety levels,adherence to treatment, common digestion symptoms and patients' satisfaction with nursing care were compared between the two groups.RESULTS: The depression and anxiety levels and the incidence of dyspeptic symptoms were significantly lower in the study group than in the control group (P ＜ 0.05).The adherence to treatment and patients' satisfaction with nursing care were significantly higher in the study group than in the control group (58.0％ vs 30.0％, 92.0％ vs 58.0％, P ＜ 0.05 for both).CONCLUSION: Humanistic nursing intervention can significantly reduce the depression and anxiety levels and the incidence of the dyspeptic symptoms, and improve the adherence to treatment and the patients' satisfaction with nursing care in patients with functional dyspepsia with depression.