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Interactions between drug metabolizing enzymes and traditional Chinese medicine

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 7

DOI:: 10.11569/wcjd.v24.i7.994

Key Word:: 中药;肝脏药物代谢酶;配伍;相互作用;Traditional Chinese medicine;Drug metabolizing enzyme;Compatibility;Interaction

Abstract： Drug metabolizing enzymes are key in determining the fate of drugs, and their inhibitory or inducing effects are the primary mechanism of drug interactions.In this paper, we discuss the method for detecting the interactions between drug metabolizing enzymes and traditional Chinese medicine;identify the possible substrates of drug metabolizing enzymes at the level of active ingredients, effective group and decoction pieces;analyze the effect of traditional Chinese medicine on drug metabolizing enzymes at the levels of mRNA, protein and the enzyme activity, as well as the inhibitory or inducing effects of chemical components on metabolizing enzymes;identify the specific subtype;and clarify the metabolic processes, the basis of compatibility, and interactions between drug metabolizing enzyme and traditional Chinese medicine, with an aim to provide the basis for compatibility and rational administration in dinical practice.

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