Paper - WANFANG MED ONLINE

You Position: Home > Paper

Functions of large intergenic non-coding RNA-regulator of reprogramming

( views:16, downloads:0 )

Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 3

DOI:: 10.11569/wcjd.v24.i3.331

Key Word:: 长链非编码RNA;胚胎干细胞;诱导多能性干细胞;ROR;p53;Large non-coding RNAs;Embryonic stem cells;Induced pluripotent stem cells;Regulator of reprogramming;p53

Abstract：在人类基因组中,存在大量的非编码RNA(non-coding RNAs,ncRNAs).近年来随着研究的发展,这些ncRNA已成为继microRNAs和siRNAs之后又一研究热点.长链ncRNA-ROR(large intergenic ncRNA-regulator of reprogramming,lincRNA-ROR),是最新发现对细胞重编程过程具有重要调控作用的长链非编码RNA.现有的研究表明,ROR在诱导多能性干细胞(induced pluripotent stem cells,iPSCs)形成、DNA损伤、氧化应激等过程中发挥重要的作用;此外,在肿瘤中,目前发现ROR与乳腺癌、肝癌的发生、转移等密切相关.ROR拥有丰富的生物学功能,但其具体的作用机制尚不明确,本文就ROR的研究背景、发现过程、功能及特点做一概述,对其在肿瘤上的作用及相关调控机制的进行探讨.

Reference

[1]P, Hou,Y, Zhao,Z, Li,etc.LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis.[J].2014,5.
[2]Mercer TR,Dinger ME,Mattick JS.Long non-coding RNAs: insights into functions.[J].2009,10(3).
[3]Manuel Garber,Courtney French,Bradley E. Bernstein,etc.Chromatin Signature Reveals Over A Thousand Highly Conserved Large Non-coding Rnas In Mammals[J].2009,458(7235).
[4]Martin C, Frith,Timothy L, Bailey,Takeya, Kasukawa,etc.Discrimination of non-protein-coding transcripts from protein-coding mRNA.[J].1900,3(1).
[5]Sablina AA,Budanov AV,Ilyinskaya GV,etc.The antioxidant function of the p53 tumor suppressor.[J].2005,11(12).
[6]Yates MS,Wakabayashi J,Shin S.Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.[J].2009,620(1).
[7]Morin RD,O'Connor MD,Griffith M,etc.Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells.[J].2008,18(4).
[8]Cheng,E.-C.,Lin,H..Repressing the repressor: A lincRNA as a microRNA sponge in embryonic stem cell self-renewal[J].2013,25(1).
[9]Fraser, P.,Nagano, T..No-nonsense functions for long noncoding RNAs[J].2011,145(2).
[10]Diederichs,S.,Gutschner,T..The hallmarks of cancer: A long non-coding RNA point of view[J].2012,9(6).
[11]J B, GURDON.The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles.[J].1962,10.
[12]Mitchell Guttman,John L. Rinn.Modular regulatory principles of large non- coding RNAs[J].2012,482(Feb.16 TN.7385).
[13]Kenji Takahashi,Irene K. Yan,Takayuki Kogure,etc.Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer[J].2014,4.
[14]John R, Prensner,Arul M, Chinnaiyan.The emergence of lncRNAs in cancer biology.[J].2011,1(5).
[15]Yamanaka,S..Induced pluripotent stem cells: Past, present, and future[J].2012,10(6).
[16]Ali ZHANG,Nanjiang Zhou,Jianguo Huang,etc.The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage[J].2013,(3).
[17]Chang, Howard Y. .,Wapinski, Orly.Long noncoding RNAs and human disease[J].2011,21(6).
[18]Sunwoo H,Wilusz JE,Spector DL.Long noncoding RNAs: functional surprises from the RNA world.[J].2009,23(13).
[19]Chang HY,Wang KC.Molecular mechanisms of long noncoding RNAs.[J].2011,43(6).
[20]Yachechko, R,Pyle, AD,Richter, L,etc.Generation of human induced pluripotent stem cells from dermal fibroblasts[J].2008,105(8).
[21]Chen W,Sun Z,Wang XJ,etc.Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response.[J].2009,34(6).
[22]Lunter G,Ponjavic J,Ponting CP.Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs.[J].2007,17(5).
[23]Cesana, M.,Cacchiarelli, D.,Legnini, I.,etc.A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA[J].2011,147(2).
[24]Takahashi,K.,Yan,I.K.,Haga,H.,etc.Modulation of hypoxia-signaling pathways by extracellular linc-RoR[J].2014,127(7).
[25]Prives, C,Vousden, KH.Blinded by the Light: The Growing Complexity of p53[J].2009,137(3).
[26]Andrei V. Budanov.The Role of Tumor Suppressor p53 In the Antioxidant Defense and Metabolism[J].2014,85.
[27]Loewer S,Cabili MN,Guttman M,etc.Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.[J].2010,42(12).
[28]胡谦,胡小云.长链非编码RNA在胃癌中的研究进展[J].2014,(4).
[29].Finishing the euchromatic sequence of the human genome.[J].2004,431(7011).
[30]Tay, Y.,Kats, L.,Salmena, L.,etc.Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs[J].2011,147(2).
[31]Ewan A, Gibb,Carolyn J, Brown,Wan L, Lam.The functional role of long non-coding RNA in human carcinomas.[J].2011,10.
[32]Tsai,J.J.,Dudakov,J.A.,Takahashi,K.,etc.Nrf2 regulates haematopoietic stem cell function[J].2013,15(3).
[33]Nina, Hauptman,Damjan, Glava.Long non-coding RNA in cancer.[J].2013,14(3).
[34]Shen J,Niture SK,Kaspar JW,etc.Nrf2 signaling and cell survival.[J].2010,244(1).
[35]J A, Thomson,J, Itskovitz-Eldor,S S, Shapiro,etc.Embryonic stem cell lines derived from human blastocysts.[J].1998,282(5391).
[36].Opposing microRNA families regulate self-renewal in mouse embryonic stem cells[J].2010,463(Feb.4 TN.7281).
[37]Kaspar JW,Niture SK,Jaiswal AK.Nrf2:INrf2 (Keap1) signaling in oxidative stress.[J].2009,47(9).
[38]Xu, N,Papagiannakopoulos, T,Pan, GJ,etc.MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells[J].2009,137(4).
[39]Levine SS,Ray MK,Brambrink T,etc.Polycomb complexes repress developmental regulators in murine embryonic stem cells[J].2006,441(7091).
[40]Asher, Gad,Tsvetkov, Peter,Kahana, Chaim,etc.A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.[J].2005,19(3).
[41]Peterson C,Ott V,Lavon N,etc.Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.[J].2009,5(1).