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Relationship between Hedgehog signaling pathway and pancreatic cancer

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 1

DOI:: 10.11569/wcjd.v24.i1.75

Key Word:: Hedgehog;信号通路;胰腺癌;Hedgehog;Signaling pathway;Pancreatic cancer

Abstract： Hedgehog(Hh)信号通路主要是由配体蛋白Hh、蛋白受体蛋白Patched(Ptch)、跨膜蛋白Smo、核转录因子Gli蛋白及下游靶基因组成.该通路在胚胎时期的细胞分化、组织发育及器官形成中扮演重要角色,近年来其已被报道在胰腺癌发生和进展中发挥重要的作用,他能够诱导胰腺癌细胞的分化、增殖和侵袭,还与胰腺癌干细胞的特性密切相关,因此阻断胰腺癌细胞中Hh信号传导通路将为胰腺癌的治疗提供一个新的有效手段.在这篇综述中,我们将总结Hh信号通路的组成、传导机制以及他与胰腺癌发生发展的关系.

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