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Role of phosphatase of regenerating liver 3 in gastric carcinoma

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Author:: No author available

Journal Title:: World Chinese Journal of Digestology

Issue:: 1

DOI:: 10.11569/wcjd.v24.i1.59

Key Word:: 肝再生磷酸酶-3;胃癌;淋巴转移;腹膜转移;复发;Phosphatase of regenerating liver 3;Gastric carcinoma;Lymphatic metastasis;Peritoneal metastasis;Recurrence

Abstract：胃癌是世界范围内常见肿瘤之一,因胃癌死亡的患者数占据肿瘤相关死因的第3位.肝再生磷酸酶-3(phosphatase of regeneratingliver 3,PRL-3)作为一个新近发现的蛋白酪氨酸磷酸酶,近年来研究发现其在胃癌组织中高表达,在胃癌淋巴转移、腹膜转移等发挥重要作用,与胃癌患者预后负相关.其后,越来越多的研究关注其在胃癌发生、发展中的调控机制,以期阐明PRL-3在胃癌发生、发展中的具体调节通路及影响因素.尽管随着研究的不断深入,对于PRL-3在胃癌中的作用机制得到一部分阐释,但对于PRL-3在促进胃癌淋巴转移、腹膜转移等恶性进展及复发的机制仍然不是很清楚,本文即对近年来PRL-3的相关研究进展作一综述.

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