Relationship among Helicobacter pylori infection,gut hormones and diabetic gastroparesis
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 15
- DOI:
- 10.3969/j.issn.1009-3079.2010.15.019
- Key Word:
- 糖尿病胃轻瘫;幽门螺杆菌;胃泌素;生长抑素
Abstract： 目的:探讨糖尿病胃轻瘫(DGP)患者血清胃泌素(GAS)、生长抑素(SS)及幽门螺杆菌(H.pylon)在DGP中的作用及相关性.方法:2型糖尿病患者56例,经核素标记胃半排时间测定分为单纯糖尿病组与DGP组.非糖尿病对照组患者47名,经核素标记胃半排时间测定分为正常对照组与单纯胃轻瘫组.应用快速尿素酶实验法及Giemsa染色法检查各组病例胃窦黏膜H.pylori.应用放射免疫法测定各组病例血清GAS、SS含量.结果:快速尿素酶实验法和Giemsa染色法检测H.pylori在各组中均无差别.单纯糖尿病组与正常对照组的H.pylori检出率无明显差异;单纯胃轻瘫组的H.pylori检出率显著高于正常对照组(快速尿素酶实验法:73.3% vs 47.1%,P<0.05);DGP组的H.pylori检出率显著高于正常对照组(快速尿素酶实验法:87.8% vs 47.1%,P<0.01;Giemsa染色法:81.9% vs 41.2%,P<0.01)、单纯糖尿病组(快速尿素酶实验法:87.8% vs47.8%,P<0.01;Giema染色法:81.9%vs 43.5%,P<0.05)及单纯胃轻瘫组(快速尿素酶实验法:87.8% vs 73.3%,P<0.01;Giemsa染色法:81.9%vs 66.7%,P<0.01).H.pylori(+)组:DPG组的GAS均高于正常对照组(147.58±16.68 vs 80.91±15.23,P<0.01),SS低于正常对照组(16.29±4.27vs 47.81±16.88,P<0.01);H.pylori(-)组:各组的GAS和SS水平无明显差异.结论:pylori感染可使DGP患者GAS升高,SS降低,H.pylori感染导致的胃黏膜病变与糖尿病胃轻瘫有密切关系.
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