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Advances in research on Barrett's esophagus

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 5

DOI:: 10.3969/j.issn.1009-3079.2010.05.011

Key Word:: Barrett's食管;食管腺癌;胃食管反流病;幽门螺杆菌;酸暴露;骨髓干细胞;miRNAs

Abstract：近年来,食管腺癌的发病率日益增高.Barrett's食管是一种癌前病变,食管下段复层鳞状上皮被异常的柱状上皮所取代,是长期胃食管反流所造成的结果.胃酸和十二指肠内容物对Barrett's食管的发生、发展起着重要的作用.Barrett's食管、胃食管连接处肠化和贲门肠化的定义和组织学诊断标准仍未统一,胃食管反流病和幽门螺杆菌感染的关系目前仍不清楚.最新的研究表明,Barrett's食管不是食管本身对损伤的修复,而是起源于骨髓干细胞.miRNAS与Barrett's食管癌变机制及其预后密切相关,为临床上有价值的预后发展的分子生物学标毛是一种潜在新的药物治疗靶点.

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