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Effects of intracerebral microinjection of 5-hydroxytryptamine and its blocking agents and intracerebral microelectric stimulation on gastric electrical activity in rabbits

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
31
DOI:
10.3969/j.issn.1009-3079.2009.31.002
Key Word:
5-羟色胺;室旁核;中缝大核;昂丹司琼;赛庚啶

Abstract: 目的:观察室旁核及中缝大核微注射5-羟色胺(5-hydroxytryptamine,5-HT)及其各种阻断剂和电刺激对家兔胃电活动的影响,探讨室旁核影响胃肠运动的中枢地位.方法:注射5-HT及其各种阻断剂和电刺激家兔室旁核,然后采用胃浆膜双极4导联同步记录,分析其胃体、胃窦部胃电的平均频率、相位差、负相位比率、波形对应率、幅度等指标,考察室旁核及中缝大核微量注射5-HT及各种阻断剂和电刺激对家兔胃电活动的影响.结果:室旁核注射2μg 5-HT后,除胃体3外胃电频率均加快,其中胃体2差异显著(4.44±0.09 vs 4.24±0.09,P=0.034),再注射5μg丹司琼后胃电频率均减慢,其中胃体2、3差异显著(P=0.032,0.043);室旁核注射2 μg 5-HT再注射5μg赛庚啶后,胃电频率加快,胃体2差异显著(P=0.044);室旁核电刺激后,除胃体2外胃电频率均减慢,胃体1和胃体3差异显著(P=0.03,0.029);中缝大核注射10μg 5-HT后,胃体2胃电频率明显减慢(4.13±0.11 vs 4.33±0.09,P=0.021),再注射10μg赛庚啶后,胃体2胃电频率则加快(P=0.034);注射10μg 5-HT再室旁核电刺激后,除胃体1外胃电频率均减慢,胃窦部位差异显著(3.93±0.14 vs 4.46±0.14,P=0.006).结论:室旁核微量注射5-HT对胃电活动主要为激动作用,可能是通过5-HT3受体途径发挥作用:而中缝大核注射5-HT则为抑制作用,可能是通过5-HT3受体途径发挥作用;中缝大核微量注射5-HT的同时室旁核电刺激对胃电的抑制似具协同作用,进一步证实了中枢同时存在"下行性抑制"和"下行性兴奋"两个系统共同调控消化道功能的概念.

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