You Position: Home > Paper
Association of M235T variants of angiotensinogen gene with hepatocirrhosis
( views:161, downloads:8 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 24
- DOI:
- 10.3969/j.issn.1009-3079.2009.24.015
- Key Word:
- 血管紧张素原;遗传多态性;肝硬化
Abstract： 目的: 探讨血管紧张素原(angiotensinogen,AGT)基因M235T分子变异与肝硬化的关系.方法: 提取肝硬化患者和正常人白细胞基因组DNA, 通过PCR、限制性片段长度多态性和测序等技术, 观察在正常组和肝硬化组的不同基因型的分布和等位基因频率的差异.结果: AGT基因 M235T 位点MM、MT和TT基因型的分布在肝硬化组和正常组分别为: 7.8%、40.6%、51.6%与8.0%、59.7%、32.3%, 两组之间不存在差异(χ2=5.120,P>0.05).结论: AGT基因M235T变异可能与肝硬化没有显著关系.
- [1]魏红山,李定国,陆汉明,等.血管紧张素Ⅱ对肝星状细胞增殖及胶原合成影响[J].2001,(3).
- [2]魏红山,李定国,陆汉明,等.肾素-血管紧张素系统与肝纤维化发生[J].2001,(3).
- [3]Ryoichiro Kageyama,Hiroaki Ohkubo,Shigetada Nakanishi.Induction of rat liver angiotensinogen mRNA following acute inflammation[J].1985,129(3).
- [4]Spence E,Thorburn D,Smith CA,etc.Polymorphisms of the renin-angiotensin system and the severity of fibrosis in chronic hepatitis C virus infection.[J].2005,12(5).
- [5]Sethi AA,Gronholdt ML,Jensen G,etc.Angiotensinogen single nucleotide polymorphisms, elevated blood pressure, and risk of cardiovascular disease.[J].2003,41(6).
- [6]Xiao F,Wei H,Song C,etc.Polymorphisms in the promoter region of the angiotensinogen gene are associated with liver cirrhosis in patients with chronic hepatitis B.[J].2006,21(9).
- [7]Murakami K,Yanai K,Nibu Y,etc.A cis-acting DNA element located between TATA box and transcription initiation site is critical in response to regulatory sequences in human angiotensinogen gene.[J].1996,271(27).
- [8]F, Cumin,D, Le-Nguyen,B, Castro,etc.Comparative enzymatic studies of human renin acting on pure natural or synthetic substrates.[J].1987,913.
- [9]D J, Campbell.Tissue renin-angiotensin system: sites of angiotensin formation.[J].1987,10 Suppl 7.